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Literature summary for 2.7.11.10 extracted from

  • Hansberger, M.W.; Campbell, J.A.; Danthi, P.; Arrate, P.; Pennington, K.N.; Marcu, K.B.; Ballard, D.W.; Dermody, T.S.
    IkappaB kinase subunits alpha and gamma are required for activation of NF-kappaB and induction of apoptosis by mammalian reovirus (2007), J. Virol., 81, 1360-1371.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.10

Protein Variants

Protein Variants Comment Organism
additional information IKK subunit-specific small interfering RNAs and cells deficient in individual IKK subunits show that IKKalpha subunit, not IKKbeta, is required for reovirus-induced NF-kappaB activation and apoptosis, overview, NF-kappaB activation and apoptosis are delayed in cells deficient in the IKK complex components IKKgamma/NEMO, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Homo sapiens
Mn2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens IKK is responsible for activation of NF-kappaB by initiating the degradation of the NF-kappaB inhibitor IkappaB, subunits IKKalpha and IKKgamma/NEMO, not IKKbeta, are required for reovirus-induced NF-kappaB activation and apoptosis, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information IKK is responsible for activation of NF-kappaB by initiating the degradation of the NF-kappaB inhibitor IkappaB, subunits IKKalpha and IKKgamma/NEMO, not IKKbeta, are required for reovirus-induced NF-kappaB activation and apoptosis, overview Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
oligomer the IKK complex is built by subunits IKKalpha, IKKbeta, and IKKgamma/NEMO Homo sapiens

Synonyms

Synonyms Comment Organism
IKK
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens