Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.11.10 extracted from

  • Peng, Z.; Peng, L.; Fan, Y.; Zandi, E.; Shertzer, H.G.; Xia, Y.
    A critical role for IkappaB kinase beta in metallothionein-1 expression and protection against arsenic toxicity (2007), J. Biol. Chem., 282, 21487-21496.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information no activation by arsenic nor H2O2 Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
adenoviral-mediated transient IKKbeta expression in enzyme-deficient cells significantly reduces apoptosis of the cells in response to arsenic Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information IKKbeta-/- 3T3 fibroblasts show decreased expression of antioxidant genes, such as metallothionein 1, Mt1, IKKbeta null cells display a marked increase in arsenic-induced reactive oxygen species accumulation, which leads to activation of the MKK4-c-Jun NH2-terminal kinase pathway, c-Jun phosphorylation, and apoptosis, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus IkappaB kinase beta plays a critical role in metallothionein-1 expression and protection against arsenic toxicity, two signaling pathways appear to be important for modulating arsenic toxicity. First, the IKK-NF-kappaB pathway is crucial for maintaining cellular metallothionein-1 levels to counteract reactive oxygen species accumulation, and second, when this pathway fails, excessive reactive oxygen species leads to activation of the MKK4-JNK pathway, resulting in apoptosis ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast mouse embryonic fibroblasts MEF Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information IkappaB kinase beta plays a critical role in metallothionein-1 expression and protection against arsenic toxicity, two signaling pathways appear to be important for modulating arsenic toxicity. First, the IKK-NF-kappaB pathway is crucial for maintaining cellular metallothionein-1 levels to counteract reactive oxygen species accumulation, and second, when this pathway fails, excessive reactive oxygen species leads to activation of the MKK4-JNK pathway, resulting in apoptosis Mus musculus ?
-
?

Synonyms

Synonyms Comment Organism
IkappaB kinase beta
-
Mus musculus