Activating Compound | Comment | Organism | Structure |
---|---|---|---|
NEMO | i.e. NF-kappaB essential modifier, complexing with IkappaB kinase-gamma and ubiquitination, involving the zinc finger of NEMO and c-IAP1, are required for activation of the IkappaB kinase complex by inflammatory stimuli such as tumor necrosis factor TNFalpha | Mus musculus | |
NEMO | i.e. NF-kappaB essential modifier, complexing with IkappaB kinase-gamma and ubiquitination, involving the zinc finger of NEMO and c-IAP1, are required for activation of the IkappaB kinase complex by inflammatory stimuli such as tumor necrosis factor TNFalpha | Homo sapiens | |
tumor necrosis factor TNFalpha | cytokines activate the IKK complex, mechanism, overview | Mus musculus | |
tumor necrosis factor TNFalpha | cytokines activate the IKK complex, mechanism, overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | predominantly | Mus musculus | 5737 | - |
cytoplasm | predominantly | Homo sapiens | 5737 | - |
nucleus | - |
Mus musculus | 5634 | - |
nucleus | - |
Homo sapiens | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [acetylated histone H3 protein] | Mus musculus | IKKalpha is required for histone function regulation in the nucleus | ADP + [acetylated histone H3 phosphoprotein] | - |
? | |
ATP + [acetylated histone H3 protein] | Homo sapiens | IKKalpha is required for histone function regulation in the nucleus | ADP + [acetylated histone H3 phosphoprotein] | - |
? | |
ATP + [IkappaB protein] | Mus musculus | - |
ADP + [IkappaB phosphoprotein] | - |
? | |
ATP + [IkappaB protein] | Homo sapiens | - |
ADP + [IkappaB phosphoprotein] | - |
? | |
additional information | Mus musculus | IKKalpha, not IKKbeta, is required for epidermal regeneration, IkappaB kinases are essential key regulators of the canonical and noncanonical NFkappaB pathways important for the expression of a wide variety of genes that are involved in the control of immune and inflammatory response, and in the regulation of cellular proliferation and survival, mechanism, overview | ? | - |
? | |
additional information | Homo sapiens | IKKalpha, not IKKbeta, is required for epidermal regeneration, IkappaB kinases are essential key regulators of the canonical and noncanonical NFkappaB pathways important for the expression of a wide variety of genes that are involved in the control of immune and inflammatory response, and in the regulation of cellular proliferation and survival, mechanism, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
IkappaBalpha and IkappaBbeta | - |
Mus musculus | - |
IkappaBalpha and IkappaBbeta | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
embryo | - |
Mus musculus | - |
epidermis | - |
Mus musculus | - |
fibroblast | - |
Homo sapiens | - |
fibroblast | adult and embryonic | Mus musculus | - |
HeLa cell | - |
Homo sapiens | - |
MEF cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [acetylated histone H3 protein] | IKKalpha is required for histone function regulation in the nucleus | Mus musculus | ADP + [acetylated histone H3 phosphoprotein] | - |
? | |
ATP + [acetylated histone H3 protein] | IKKalpha is required for histone function regulation in the nucleus | Homo sapiens | ADP + [acetylated histone H3 phosphoprotein] | - |
? | |
ATP + [acetylated histone H3 protein] | phosphorylation at Ser10 | Mus musculus | ADP + [acetylated histone H3 phosphoprotein] | - |
? | |
ATP + [acetylated histone H3 protein] | phosphorylation at Ser10 | Homo sapiens | ADP + [acetylated histone H3 phosphoprotein] | - |
? | |
ATP + [IkappaB protein] | - |
Mus musculus | ADP + [IkappaB phosphoprotein] | - |
? | |
ATP + [IkappaB protein] | - |
Homo sapiens | ADP + [IkappaB phosphoprotein] | - |
? | |
ATP + [IkappaBalpha protein] | phosphorylation at Ser32 and Ser36 | Mus musculus | ADP + [IkappaBalpha phosphoprotein] | - |
? | |
ATP + [IkappaBalpha protein] | phosphorylation at Ser32 and Ser36 | Homo sapiens | ADP + [IkappaBalpha phosphoprotein] | - |
? | |
ATP + [IkappaBbeta protein] | phosphorylation at Ser19 and Ser23 | Mus musculus | ADP + [IkappaBbeta phosphoprotein] | - |
? | |
ATP + [IkappaBbeta protein] | phosphorylation at Ser19 and Ser23 | Homo sapiens | ADP + [IkappaBbeta phosphoprotein] | - |
? | |
additional information | IKKalpha, not IKKbeta, is required for epidermal regeneration, IkappaB kinases are essential key regulators of the canonical and noncanonical NFkappaB pathways important for the expression of a wide variety of genes that are involved in the control of immune and inflammatory response, and in the regulation of cellular proliferation and survival, mechanism, overview | Mus musculus | ? | - |
? | |
additional information | IKKalpha, not IKKbeta, is required for epidermal regeneration, IkappaB kinases are essential key regulators of the canonical and noncanonical NFkappaB pathways important for the expression of a wide variety of genes that are involved in the control of immune and inflammatory response, and in the regulation of cellular proliferation and survival, mechanism, overview | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | the IKK complex consists of 3 subunits: catalytic IKKalpha and IKKbeta, and noncatalytic NEMO/IKKgamma | Homo sapiens |
More | the IKK complex consists of 3 subunits: catalytic IKKalpha and IKKbeta, and noncatalytic, regulatory NEMO/IKKgamma | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
IKK | - |
Mus musculus |
IKK | - |
Homo sapiens |
inhibitor of kappaB kinase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus | |
ATP | - |
Homo sapiens |