Literature summary for 2.7.11.10 extracted from

Fitzgerald, K.A.; McWhirter, S.M.; Faia, K.L.; Rowe, D.C.; Latz, E.; Golenbock, D.T.; Coyle, A.J.; Liao, S.M.; Maniatis, T.
IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway (2003), Nat. Immunol., 4, 491-496.

Search for more literature for 2.7.11.10

Cloned(Commentary)

Cloned (Comment)	Organism
transient coexpression of IKKepsilon, IRF3, and TBK1 or IKKbeta in 293T cells, transient coexpression of IFN-beta or ISRE reporter genes and IKKepsilon or TBK1 in HEK293 cells with or without FLAG or GFP tag	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	IKKepsilon and TBK1 interference RNA blocks IRF3 activation	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	the noncanonical IkappaB kinase homologue IKKepsilon, beneath TANK-binding kinase-1 TBK-1, is required for activation of transcription factor NFkappaB and of interferon regulatory factor 3 IRF3, regulation and interaction, overview	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	IKKepsilon is a noncanonical IkappaB kinase homologue	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	the noncanonical IkappaB kinase homologue IKKepsilon, beneath TANK-binding kinase-1 TBK-1, is required for activation of transcription factor NFkappaB and of interferon regulatory factor 3 IRF3, regulation and interaction, overview	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
IKKepsilon	-	Homo sapiens

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Release 2023.1 (January 2023)