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Literature summary for 2.7.11.10 extracted from
- IKKbeta is required for peripheral B cell survival and proliferation (2003), J. Immunol., 170, 4630-4637.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | IKKbeta-deficient B-cells are impaired in mitogenic responses to lipopolysaccharides, anti-CD40, and anti-IgM, and show high reduction of all peripheral B-cell subsets due to associated defects in cell survival | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | IKKbeta is required for regulation of NFkappaB activity and peripheral B cell survival and proliferation | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
C57BL/6 wild-type mice or murine strains deficient in either subunits IKKalpha, IKKbeta, or IKKgamma, overview | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| B-cell | peripheral | Mus musculus | - |
| B-lymphocyte | peripheral | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | IKKbeta is required for regulation of NFkappaB activity and peripheral B cell survival and proliferation | Mus musculus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | the IKK complex consists of 3 subunits: catalytic IKKalpha and IKKbeta, and regulatory IKKgamma | Mus musculus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| IKK complex | - |
Mus musculus |
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Release 2023.1 (January 2023)
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