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Literature summary for 2.7.11.10 extracted from

  • Piccolella, E.; Spadaro, F.; Ramoni, C.; Marinari, B.; Costanzo, A.; Levrero, M.; Thomson, L.; Abraham, R.T.; Tuosto, L.
    Vav-1 and the IKKalpha subunit of IkappaB kinase functionally associate to induce NF-kappaB activation in response to CD28 engagement (2003), J. Immunol., 170, 2895-2903.
    View publication on PubMed
Search for more literature for 2.7.11.10

Activating Compound

Activating Compound Comment Organism Structure
CD28 activates Vav-1/IKKalpha and subsequently NFkappaB, meditated by Vav-1 Homo sapiens
Vav-1 cytoplasmic proto-oncogene, constitutively associates with IKKalpha in Jurkat and primary CD4+ cells Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
transient expression of HA-tagged IKKalpha, IKKbeta, and IKKalpha mutant L605R/F606P in Jurkat cells, transient coexpression of myc-tagged Vav-1 and IKKalpha in Jurkat cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
L605R/F606P IKKalpha mutant, defective in HLH domains, unable to bind wild-type Vav-1 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane in T-cells Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens Vav-1 and IKKalpha subunit of IkappaB kinase functionally associate to induce NFkappaB activation in response to CD28 engagement ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
JURKAT cell
-
 Homo sapiens
-
peripheral blood mononuclear cell CD4+ Homo sapiens
-
T-cell
-
 Homo sapiens
-
T-lymphocyte
-
 Homo sapiens
-
thymocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Vav-1 and IKKalpha subunit of IkappaB kinase functionally associate to induce NFkappaB activation in response to CD28 engagement Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
IKK
-
 Homo sapiens