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Literature summary for 2.7.11.10 extracted from

  • Ruocco, M.G.; Maeda, S.; Park, J.M.; Lawrence, T.; Hsu, L.C.; Cao, Y.; Schett, G.; Wagner, E.F.; Karin, M.
    IkappaB kinase IKKbeta, but not IKKalpha, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss (2005), J. Exp. Med., 201, 1677-1687.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.10

Protein Variants

Protein Variants Comment Organism
additional information construction of IKKalpha-deficient and of IKKbeta-deficient mice and BM cell mutants, the mutants show defective osteoclastogenesis, wild-type osteoblasts can rescue osteoclastogenesis in IKKalpha- and IKKbeta-defective mutant BM cells, exogenic TNFalpha can rescue only IKKalpha-deficient mutants, TNFR1 can rescue IKKbeta-deficient osteoclast progenitors, but not prevent TNFalpha-induced apoptosis, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Mus musculus 5737
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus IKK is involved in NF-kappaB activation, IkappaB kinase IKKbeta, but not IKKalpha, is a critical mediator of NF-kappaB-dependent osteoclast survival preventing TNFalpha-induced cell death, and is required for formation of fully functional bone-resorbing osteoclasts and for inflammation-induced bone loss ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bone
-
 Mus musculus
-
hematopoietic cell
-
 Mus musculus
-
osteoblast
-
 Mus musculus
-
osteoclast
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information IKK is involved in NF-kappaB activation, IkappaB kinase IKKbeta, but not IKKalpha, is a critical mediator of NF-kappaB-dependent osteoclast survival preventing TNFalpha-induced cell death, and is required for formation of fully functional bone-resorbing osteoclasts and for inflammation-induced bone loss Mus musculus ?
-
 ?

Subunits

Subunits Comment Organism
More the IKK complex consists of 3 subunits: catalytic IKKalpha and IKKbeta, and noncatalytic NEMO/IKKgamma, complexes of IKKalpha and IKKgamma or IKKalpha homodimers are not stable Mus musculus

Synonyms

Synonyms Comment Organism
IKK
-
 Mus musculus