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Literature summary for 2.7.11.10 extracted from
- IKK/NF-kappaB signaling: balancing life and death - a new approach to cancer therapy (2005), J. Clin. Invest., 115, 2625-2632.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| TNFalpha | and other cytokines, activation of IKK activating NF-kappaB | Mus musculus | |
| TNFalpha | and other cytokines, activation of IKK activating NF-kappaB | Homo sapiens |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | inhibition of IKK-driven NF-kappaB activation offers a strategy for treatment of different malignancies and can convert inflammation-induced tumor growth to inflammation-induced tumor regression | Homo sapiens |
| pharmacology | IKKbeta/NF-kappaB inhibitors can be useful adjuvants for conventional chemotherapeutic drugs, ionizing radiation, or tumoricidal cytokines, e.g. IFNs or TRAIL | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | construction of IKK knockout mice as a model system for drug development | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Acetylsalicylic acid | nonspecific for IKK, anti-inflammatory | Homo sapiens |  |
| Acetylsalicylic acid | nonspecific for IKK, anti-inflammatory | Mus musculus | |
| arsenic trioxide | nonspecific for IKK, acts on a cystein ersidue in the activation loop | Homo sapiens | |
| arsenic trioxide | nonspecific for IKK, acts on a cystein ersidue in the activation loop | Mus musculus | |
| AS602868 | IKKbeta inhibitor | Homo sapiens | |
| AS602868 | IKKbeta inhibitor | Mus musculus | |
| cyclopentenone prostaglandins | nonspecific for IKK, anti-inflammatory | Homo sapiens | |
| cyclopentenone prostaglandins | nonspecific for IKK, anti-inflammatory | Mus musculus | |
| sulfasalazine | nonspecific for IKK, anti-inflammatory | Homo sapiens | |
| sulfasalazine | nonspecific for IKK, anti-inflammatory | Mus musculus | |
| sulindac sulfide | nonspecific for IKK, anti-inflammatory | Homo sapiens | |
| sulindac sulfide | nonspecific for IKK, anti-inflammatory | Mus musculus | |
| trans-resveratrol | nonspecific for IKK, anti-inflammatory | Homo sapiens | |
| trans-resveratrol | nonspecific for IKK, anti-inflammatory | Mus musculus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Mus musculus | 5737 | - |
| cytoplasm | - |
Homo sapiens | 5737 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + [IkappaB protein] | Mus musculus | - |
ADP + [IkappaB phosphoprotein] | - |
? | |
| ATP + [IkappaB protein] | Homo sapiens | - |
ADP + [IkappaB phosphoprotein] | - |
? | |
| additional information | Mus musculus | IKK activates NF-kappaB which initiates signaling pathways that play critical roles in a variety of physiological and pathological processes, e.g. promotion of cell survival inducing production of apoptosis inhibitors in normal and cancer cells, pathways overview, IKK/NF-kappaB links inflammation to cancer, regulation of IKK, overview | ? | - |
? | |
| additional information | Homo sapiens | IKK activates NF-kappaB which initiates signaling pathways that play critical roles in a variety of physiological and pathological processes, e.g. promotion of cell survival inducing production of apoptosis inhibitors in normal and cancer cells, pathways overview, IKK/NF-kappaB links inflammation to cancer, regulation of IKK, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| epidermis | - |
Homo sapiens | - |
| hepatocyte | - |
Mus musculus | - |
| hepatoma cell | - |
Mus musculus | - |
| JURKAT cell | - |
Homo sapiens | - |
| keratinocyte | epidermal | Homo sapiens | - |
| squamous cell carcinoma cell | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + [IkappaB protein] | - |
Mus musculus | ADP + [IkappaB phosphoprotein] | - |
? | |
| ATP + [IkappaB protein] | - |
Homo sapiens | ADP + [IkappaB phosphoprotein] | - |
? | |
| additional information | IKK activates NF-kappaB which initiates signaling pathways that play critical roles in a variety of physiological and pathological processes, e.g. promotion of cell survival inducing production of apoptosis inhibitors in normal and cancer cells, pathways overview, IKK/NF-kappaB links inflammation to cancer, regulation of IKK, overview | Mus musculus | ? | - |
? | |
| additional information | IKK activates NF-kappaB which initiates signaling pathways that play critical roles in a variety of physiological and pathological processes, e.g. promotion of cell survival inducing production of apoptosis inhibitors in normal and cancer cells, pathways overview, IKK/NF-kappaB links inflammation to cancer, regulation of IKK, overview | Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | the IKK complex consists of 3 subunits: catalytic IKKalpha and IKKbeta, and noncatalytic, regulatory NEMO/IKKgamma | Mus musculus |
| More | the IKK complex consists of 3 subunits: catalytic IKKalpha and IKKbeta, and noncatalytic, regulatory NEMO/IKKgamma | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| IKK | - |
Mus musculus |
| IKK | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Mus musculus | |
| ATP | - |
Homo sapiens | |
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