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Literature summary for 2.7.11.10 extracted from

  • Takada, Y.; Kobayashi, Y.; Aggarwal, B.B.
    Evodiamine abolishes constitutive and inducible NF-kB activation by inhibiting IkBalpha kinase Activation, Thereby Suppressing NF-kB-regulated antiapoptotic and metastatic gene expression, up-regulating apoptosis, and inhibiting invasion (2005), J. Biol. Chem., 280, 17203-17212.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
evodiamine alkaloid extracted from Evodia rutaecarpa fruits exhibiting antiproliferative, antimetastatic, and apoptotic activities, inhibits IKKalpha activity, suppresses IKKalpha phosphorylation and degradation, and specifically blocks NF-kappaB activation by IKK and other agents, translocation, and activity, overview Homo sapiens
additional information evodiamine analogue rutaecarpine does not inhibit IKK and NF-kappaB activation Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Homo sapiens 5737
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [IkappaBalpha protein] Homo sapiens
-
ADP + [IkappaBalpha phosphoprotein]
-
?
additional information Homo sapiens IKK activates NF-kappaB through action of TNFalpha playing an important role in subsequent signaling pathways involved in e.g. apoptosis/cell survival, cell proliferation, and inflammation ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell embryonic kidney cell line Homo sapiens
-
JURKAT cell T-cell lymphoma cell line Homo sapiens
-
KBM-5 cell myeloid leukemia cell line Homo sapiens
-
NCI-H1299 cell lung adenocarcinoma cell line Homo sapiens
-
U-266 cell multiple myeloma cell line Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [IkappaBalpha protein]
-
Homo sapiens ADP + [IkappaBalpha phosphoprotein]
-
?
additional information IKK activates NF-kappaB through action of TNFalpha playing an important role in subsequent signaling pathways involved in e.g. apoptosis/cell survival, cell proliferation, and inflammation Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
IkappaBalpha kinase
-
Homo sapiens
IkappaBbeta kinase
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens