Inhibitors | Comment | Organism | Structure |
---|---|---|---|
evodiamine | alkaloid extracted from Evodia rutaecarpa fruits exhibiting antiproliferative, antimetastatic, and apoptotic activities, inhibits IKKalpha activity, suppresses IKKalpha phosphorylation and degradation, and specifically blocks NF-kappaB activation by IKK and other agents, translocation, and activity, overview | Homo sapiens | |
additional information | evodiamine analogue rutaecarpine does not inhibit IKK and NF-kappaB activation | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [IkappaBalpha protein] | Homo sapiens | - |
ADP + [IkappaBalpha phosphoprotein] | - |
? | |
additional information | Homo sapiens | IKK activates NF-kappaB through action of TNFalpha playing an important role in subsequent signaling pathways involved in e.g. apoptosis/cell survival, cell proliferation, and inflammation | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | embryonic kidney cell line | Homo sapiens | - |
JURKAT cell | T-cell lymphoma cell line | Homo sapiens | - |
KBM-5 cell | myeloid leukemia cell line | Homo sapiens | - |
NCI-H1299 cell | lung adenocarcinoma cell line | Homo sapiens | - |
U-266 cell | multiple myeloma cell line | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [IkappaBalpha protein] | - |
Homo sapiens | ADP + [IkappaBalpha phosphoprotein] | - |
? | |
additional information | IKK activates NF-kappaB through action of TNFalpha playing an important role in subsequent signaling pathways involved in e.g. apoptosis/cell survival, cell proliferation, and inflammation | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IkappaBalpha kinase | - |
Homo sapiens |
IkappaBbeta kinase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |