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Literature summary for 2.7.11.1 extracted from

  • Mohl, B.; Roy, P.
    Cellular casein kinase 2 and protein phosphatase 2A modulate replication site assembly of bluetongue virus (2016), J. Biol. Chem., 291, 14566-14574 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.1

Inhibitors

Inhibitors Comment Organism Structure
4,5,6,7-tetrabromobenzotriazole an ATP/GTP-competitive inhibitor of CK2 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + non-structural protein 2 non-structural protein 2 from bluetongue virus (BTV) Homo sapiens ADP + phospho-non-structural protein 2
-
 ?

Synonyms

Synonyms Comment Organism
casein kinase 2
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction CK2 inhibition or protein phosphatase 2A activation decrease NS2 phosphorylation Homo sapiens
physiological function human host cell CK2 activity is important for bluetongue virus (BTV) replication. Host cell factor, protein phosphatase 2A, PP2A, is involved in NS2 dephosphorylation and, together with CK2, regulates viral inclusion bodies, VIBs, morphology and virus replication. Viral VIBs are predominantly comprised of a BTV-encoded non-structural protein 2, NS2. The two host enzymes influence the dynamic nature of VIB assembly/disassembly, and these concerted activities may be relevant to the assembly and the release of these cores from VIBs Homo sapiens