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Literature summary for 2.7.11.1 extracted from

  • Kim, S.; Ezhilarasan, R.; Phillips, E.; Gallego-Perez, D.; Sparks, A.; Taylor, D.; Ladner, K.; Furuta, T.; Sabit, H.; Chhipa, R.; Cho, J.; Mohyeldin, A.; Beck, S.; Kurozumi, K.; Kuroiwa, T.; Iwata, R.; Asai, A.; Kim, J.; Sulman, E.; Cheng, S.; Lee, L.; Nakada, M.; Guttridge, D.; DasGupta, B.; Goidts, V.; Bhat, K.P.; Nakano, I.
    Serine/threonine kinase MLK4 determines mesenchymal identity in glioma stem cells in an NF-kappaB-dependent manner (2016), Cancer Cell, 29, 201-213.
    View publication on PubMed
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Application

Application Comment Organism
medicine enzyme expression is inversely correlated with patient prognosis in mesenchymal, but not proneural high-grade gliomas Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + IKKalpha protein Homo sapiens
-
 ADP + phosphorylated IKKalpha protein
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + IKKalpha protein
-
 Homo sapiens ADP + phosphorylated IKKalpha protein
-
 ?

Synonyms

Synonyms Comment Organism
MLK4
-
 Homo sapiens
serine/threonine protein kinase
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction enzyme silencing suppresses self-renewal, motility, tumorigenesis, and radioresistance of mesenchymal glioma stem cells via a loss of the mesenchymal signature Homo sapiens
physiological function the enzyme binds and phosphorylates the nuclear factor-kappaB regulator IKKalpha, leading to activation of nuclear factor-kappaB signaling in glioma stem cells Homo sapiens