Application | Comment | Organism |
---|---|---|
medicine | GSK3 is an important therapeutic target for gliomas | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | down-regulation of GSK3 activity results in alteration of intracellular glucose metabolism resulting in dissociation of hexokinase II from the outer mitochondrial membrane with subsequent mitochondrial destabilization | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
enzastaurin | activation-related phosphorylation of Y216/Y276 is dramatically decreased following exposure to enzastaurin whereas the inhibitory phosphorylation of S21 is significantly up-regulated in glioma cells. GSK3 inhibition results in glioma cell death and reduced tumorigenicity | Homo sapiens | |
additional information | inhibition of GSK3 activity results in c-MYC activation, leading to the induction of Bax, Bim, DR4/DR5, and tumor necrosis factor-related apoptosis-inducing ligand expression and subsequent cytotoxicity. inhibition of GSK3 activity causes a dramatic decrease in intracellular nuclear factor-kappaB activity. Inhibition of GSK3 activity results in c-MYC-dependent glioma cell death through multiple mechanisms, all of which converge on the apoptotic pathways | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | - |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
glioma cell line | U251, T98, U87, U373, U118, A172 | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
glycogen synthase kinase 3 | - |
Homo sapiens |
GSK3 | - |
Homo sapiens |
serine-threonine kinase | - |
Homo sapiens |