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Literature summary for 2.7.11.1 extracted from

  • Chao, C.C.; Ma, Y.L.; Lee, E.H.
    Protein kinase CK2 impairs spatial memory formation through differential cross talk with PI-3 kinase signaling: activation of Akt and inactivation of SGK1 (2007), J. Neurosci., 27, 6243-6248.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information transfection of the dominant negative mutant of CK2, CK2alphaA156, to the CA1 area, but not to the DG area, decreases CK2 activity but enhances spatial memory formation, it increases SGK1 phosphorylation at Ser422, decreased Akt phosphorylation at Ser473, and increases cAMP response element-binding protein phosphorylation at Ser133, transfection significantly decreases CK2 activity in CA1 area by about 38%, compared to the control group, and downregulates CK2 signaling in CA1 neurons, while SGK1 phosphorylation at Ser422 is increased, overview Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
fostriecin protein phosphatase 2A inhibitor fostriecin reverses the memory-impairing effect of CK2alphaWT, it also reverses the effect of CK2alphaWT in decreasing SGK1 phosphorylation Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + Akt Rattus norvegicus CK2 phosphorylates and activates Akt directly ADP + phosphorylated Akt
-
?
additional information Rattus norvegicus CK2 impairs spatial memory formation through differential cross talk with PI-3 kinase signaling by activation of Akt and inactivation of SGK1 through protein phosphatase 2A ?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
male Sprague Dawley rats, gene CK2alpha
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + Akt CK2 phosphorylates and activates Akt directly Rattus norvegicus ADP + phosphorylated Akt
-
?
ATP + Akt CK2 phosphorylates and activates Akt directly, phosphorylation at Ser473 Rattus norvegicus ADP + phosphorylated Akt
-
?
additional information CK2 impairs spatial memory formation through differential cross talk with PI-3 kinase signaling by activation of Akt and inactivation of SGK1 through protein phosphatase 2A Rattus norvegicus ?
-
?
additional information CK2 inhibition increases SGK1 phosphorylation at Ser422 Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
protein kinase CK2
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Rattus norvegicus