Activating Compound | Comment | Organism | Structure |
---|---|---|---|
fatty acids | activate PKN1 | Homo sapiens | |
Rho | activates PKN1 | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression of FLAG-tagged full-length PKN1 and of its isolated catalytic kinase domain, residues 561-942, in CHO-K1 cells, co-expression with Salmonella enterica SspH1, SspH2, YopM and IpaH9.8, all HA-tagged, in HeLa cells, interaction study, overview | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
K644E | site-directed mutagenesis, inactive mutant, PKN1 depletion causes an increase in NF-kappaB-dependent reporter gene expression | Homo sapiens |
additional information | PKN1 depletion by siRNA causes an increase in NF-kappaB-dependent reporter gene expression | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme inhibits NF-kappaB activity via interaction with the leucine-rich repeat domain of the Salmonella enterica serovar typhimurium-derived effector SspH1 in infected intestine-407 cells, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | phosphorylation at Thr774 of the activation loop is required for activity in vivo, PKN1 is phosphorylated during Salmonella enterica infection independent of SspH1 | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
intestine-407 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme inhibits NF-kappaB activity via interaction with the leucine-rich repeat domain of the Salmonella enterica serovar typhimurium-derived effector SspH1 in infected intestine-407 cells, overview | Homo sapiens | ? | - |
? | |
additional information | the catalytic kinase domain, residues 561-942, of PKN1 is active with out the regulatory domain | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PKN1 | - |
Homo sapiens |
protein kinase N1 | - |
Homo sapiens |
serine/threonine protein kinase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |