Application | Comment | Organism |
---|---|---|
drug development | CK2 is a target for drug development and design of selective inhibitors | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(5-oxo-5,6-dihydroindolo[1,2-a]quinazolin-7-yl)acetic acid | i.e. IQA | Homo sapiens | |
2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole | i.e DMAT | Homo sapiens | |
3,8-dibromo-7-hydroxy-4-methyl-2H-chromen-2-one | i.e. DBC | Homo sapiens | |
4,5,6,7-tetrabromo-1H-benzotriazole | i.e. TBB | Homo sapiens | |
8-hydroxy-4-methyl-9-nitro-2H-benzo[g]chromen-2-one | i.e. NBC | Homo sapiens | |
ellagic acid | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | CK2 is involved in phosphorylation of a large portion of the proteome, overview, increased enzyme activity in associated with a number of pathological processes, including cancer, infectious diseases, neurodegeneration, and cardiovascular pathologies playing a global anti-apoptotic role, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | CK2 is involved in phosphorylation of a large portion of the proteome, overview, increased enzyme activity in associated with a number of pathological processes, including cancer, infectious diseases, neurodegeneration, and cardiovascular pathologies playing a global anti-apoptotic role, overview | Homo sapiens | ? | - |
? | |
additional information | CK2 contains a consensus sequence in which a carboxylic acid side chain at position n+3 relative to the target serine/threonine residue plays a crucial role for activity, CK2 shows a broad substrate specificity of diverse proteins | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CK2 | - |
Homo sapiens |
protein kinase CK2 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00004 | - |
- |
Homo sapiens | ellagic acid | |
0.0001 | - |
- |
Homo sapiens | 3,8-dibromo-7-hydroxy-4-methyl-2H-chromen-2-one | |
0.00014 | - |
- |
Homo sapiens | 2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole | |
0.0003 | - |
- |
Homo sapiens | 8-hydroxy-4-methyl-9-nitro-2H-benzo[g]chromen-2-one | |
0.00039 | - |
- |
Homo sapiens | (5-oxo-5,6-dihydroindolo[1,2-a]quinazolin-7-yl)acetic acid | |
0.0005 | - |
- |
Homo sapiens | 4,5,6,7-tetrabromo-1H-benzotriazole |