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Literature summary for 2.7.11.1 extracted from

  • Agarwal-Mawal, A.; Qureshi, H.Y.; Cafferty, P.W.; Yuan, Z.; Han, D.; Lin, R.; Paudel, H.K.
    14-3-3 connects glycogen synthase kinase-3 beta to tau within a brain microtubule-associated tau phosphorylation complex (2003), J. Biol. Chem., 278, 12722-12728.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
protein 14-3-3 a dimeric scaffold protein, protein is absolutely required for connection by simultaneous binding of glycogen synthase kinase-3 beta to tau within a brain microtubule-associated tau phosphorylation complex Bos taurus

Cloned(Commentary)

Cloned (Comment) Organism
co-expression of glycogen synthase kinase-3 beta, tau, and 14-3-3 in COS-7 cells and in HEK-293 cells Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoskeleton
-
Bos taurus 5856
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [tau-protein] Bos taurus substrate of GSK3beta in brain ADP + O-phospho-[tau-protein]
-
?
additional information Bos taurus glycogen synthase kinase-3beta also performs the tau-protein kinase reaction, EC 2.7.11.26, phosphorylating tau protein at serine and threonine residues ?
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate glycogen synthase kinase-3beta also performs the tau-protein kinase reaction, EC 2.7.11.26 Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [tau-protein]
-
Bos taurus ADP + O-phospho-[tau-protein]
-
?
ATP + [tau-protein] substrate of GSK3beta in brain Bos taurus ADP + O-phospho-[tau-protein]
-
?
additional information glycogen synthase kinase-3beta also performs the tau-protein kinase reaction, EC 2.7.11.26, phosphorylating tau protein at serine and threonine residues Bos taurus ?
-
?

Synonyms

Synonyms Comment Organism
glycogen synthase kinase-3beta
-
Bos taurus
More see also EC 2.7.11.26 Bos taurus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Bos taurus