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Literature summary for 2.7.11.1 extracted from
- Functional characterization of a maize ribosomal S6 protein kinase (ZmS6K), a plant ortholog of metazoan p70(S6K) (2004), Biochemistry, 43, 533-539.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | S6K is activated by phosphorylation at Thr468 during seed germination, the process can be induced by an insulin signaling transduction pathway and blocked by rapamycin in germinating axes | Zea mays |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| ZmS6K gene DNA and amino acid sequence determination and analysis | Zea mays |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| ribosome | - |
Zea mays | 5840 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Zea mays |  |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 62000 | - |
x * 62000, S6K, SDS-PAGE | Zea mays |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + ribosomal protein S6 | Zea mays | specifically phosphorylated by S6K | ADP + phosphorylated ribosomal protein S6 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Zea mays | Q6TQF8 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| embryo | - |
Zea mays | - |
| embryonic axis | embryonic, germinating, enzyme activity increases during seed germination due to increased enzyme activation by phosphorylation at Thr468 | Zea mays | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + ribosomal protein S6 | specifically phosphorylated by S6K | Zea mays | ADP + phosphorylated ribosomal protein S6 | - |
? | |
| ATP + RSK peptide | - |
Zea mays | ADP + RSK phosphopeptide | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 62000, S6K, SDS-PAGE | Zea mays |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ribosomal S6 protein kinase | - |
Zea mays |
| S6K | - |
Zea mays |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 24 | - |
assay at | Zea mays |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
assay at | Zea mays |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Zea mays | |
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Release 2023.1 (January 2023)
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