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Literature summary for 2.7.11.1 extracted from
- The specificities of protein kinase inhibitors: an update (2003), Biochem. J., 371, 199-204.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| kenpaullone | slight activation of S6K1 | Homo sapiens |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| alsterpaullone | inhibition of AMPK, GSK3beta, S6K1, PKBalpha, PDK1, MAPKAP-K2 | Homo sapiens | |
| alsterpaullone | weak inhibition of CK1, inhibition of CK2, and slightly of MAPKAP-K1a | Rattus norvegicus | |
| indirubin-3'-monoxime | inhibition of AMPK, GSK3beta, S6K1, PKBalpha, PDK1, MAPKAP-K2 | Homo sapiens | |
| indirubin-3'-monoxime | inhibition of CK1 and MAPKAP-K1a | Rattus norvegicus | |
| kenpaullone | slight inhibition of AMPK, GSK3beta, PKBalpha, PDK1 | Homo sapiens | |
| kenpaullone | slight inhibition of MAPKAP-K1a | Rattus norvegicus | |
| additional information | no inhibition of most serine/threonine kinases by roscovitine | Homo sapiens | |
| purvalanol | inhibition of AMPK, slight inhibition of GSK3beta and S6K1, PKBalpha | Homo sapiens | |
| purvalanol | slight inhibition of CK1 and MAPKAP-K1a | Rattus norvegicus | |
| roscovitine | slight inhibition of PKBalpha and MAPKAP-K2 | Homo sapiens | |
| roscovitine | inhibition of CK1 and MAPKAP-K1a | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + casein | substrate of CK1 and CK2 | Rattus norvegicus | ADP + phosphorylated casein | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 3-phosphoinositide-dependent kinase 1 | - |
Homo sapiens |
| AMPK | - |
Homo sapiens |
| casein kinase 1 delta | - |
Rattus norvegicus |
| checkpoint kinase 1 | - |
Homo sapiens |
| Chk1 | - |
Homo sapiens |
| CK1 | - |
Rattus norvegicus |
| CK1delta | - |
Rattus norvegicus |
| CK2 | - |
Rattus norvegicus |
| GSK3beta | - |
Homo sapiens |
| MAPK-activated protein kinase 1a | - |
Rattus norvegicus |
| MAPK-activated protein kinase 2 | - |
Homo sapiens |
| MAPKAP-K1a | - |
Rattus norvegicus |
| MAPKAP-K2 | - |
Homo sapiens |
| PDK1 | - |
Homo sapiens |
| PKBalpha | - |
Homo sapiens |
| PKG | - |
Homo sapiens |
| protein kinase Balpha | - |
Homo sapiens |
| S6K1 | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 21 | - |
assay at room temperature | Homo sapiens |
| 21 | - |
assay at room temperature | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Homo sapiens |
| 7.5 | - |
assay at | Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
| ATP | - |
Rattus norvegicus | |
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