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Literature summary for 2.7.11.1 extracted from

  • Bell, D.W.; Varley, J.M.; Szydlo, T.E.; Kang, D.H.; Wahrer, D.C.; Shannon, K.E.; Lubratovich, M.; Verselis, S.J.; Isselbacher, K.J.; Fraumeni, J.F.; Birch, J.M.; Li, F.P.; Garber, J.E.; Haber, D.A.
    Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome (1999), Science, 286, 2528-2531.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens heterozygous germ line mutations in hCHK2 occur in Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in the TP53 gene. hCHK2 is a tumor suppressor gene conferring predisposition to sarcoma, breast cancer, and brain tumors ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens O96017
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information heterozygous germ line mutations in hCHK2 occur in Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in the TP53 gene. hCHK2 is a tumor suppressor gene conferring predisposition to sarcoma, breast cancer, and brain tumors Homo sapiens ?
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 ?

Synonyms

Synonyms Comment Organism
serine/threonine-protein kinase Chk2
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 Homo sapiens