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Literature summary for 2.7.11.1 extracted from
- The S. pombe aurora-related kinase Ark1 associates with mitotic structures in a stage dependent manner and is required for chromosome segregation (2001), J. Cell Sci., 114, 4371-4384.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| spindle | throughout G2 Ark1 is concentrated in one to three nuclear foci that are not associated with the spindle pole body/centromere complex. Following commitment to mitosis Ark1 associated with chromatin and is particularly concentrated at several sites including kinetochores/centromeres. Kinetochore/centromere association diminishes during anaphase A, after which it is distributed along the spindle. The protein becomes restricted to a small central zone that transiently enlarges as the spindle extends | Schizosaccharomyces pombe | 5819 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + histone H3 | Schizosaccharomyces pombe | Ark1 phosphorylates Ser10 of histone H3 in vivo | ? | - |
? |  |
| additional information | Schizosaccharomyces pombe | associates with mitotic structures in a stage dependent manner and is required for chromosome segregation | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Schizosaccharomyces pombe | O59790 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + histone H3 | Ark1 phosphorylates Ser10 of histone H3 in vivo | Schizosaccharomyces pombe | ADP + phosphorylated histone | - |
? | |
| ATP + histone H3 | Ark1 phosphorylates Ser10 of histone H3 in vivo | Schizosaccharomyces pombe | ? | - |
? | |
| additional information | associates with mitotic structures in a stage dependent manner and is required for chromosome segregation | Schizosaccharomyces pombe | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| serine/threonine-protein kinase ark1 | - |
Schizosaccharomyces pombe |
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