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Literature summary for 2.7.11.1 extracted from

  • Kobayashi, T.; Deak, M.; Morrice, N.; Cohen, P.
    Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase (1999), Biochem. J., 344, 189-197.
No PubMed abstract available
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Activating Compound

Activating Compound Comment Organism Structure
additional information activation of SGK by IGF-1 or hydrogen peroxide is initiated by a PtdIns(3,4, 5)P3-dependent activation of PDK2, which phosphorylates Ser422. This is followed by the PtdIns(3,4,5)P3-independent phosphorylation at Thr256 that activates SGK, and is catalysed by PDK1 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O00141
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Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
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kidney
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 Homo sapiens
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liver
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 Homo sapiens
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additional information SGK3 is expressed in all tissues examined, but SGK2 mRNA is only present at significant levels in liver, kidney and pancreas and, at lower levels, in the brain Homo sapiens
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pancreas
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
serine/threonine-protein kinase Sgk
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 Homo sapiens