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Literature summary for 2.7.11.1 extracted from

  • Conus, N.M.; Hannan, K.M.; Cristiano, B.E.; Hemmings, B.A.; Pearson, R.B.
    Direct identification of tyrosine 474 as a regulatory phosphorylation site for the Akt protein kinase (2002), J. Biol. Chem., 277, 38021-38028.
    View publication on PubMed
Search for more literature for 2.7.11.1

Activating Compound

Activating Compound Comment Organism Structure
pervanadate activation of Akt is associated with tyrosine phosphorylation of Akt Homo sapiens
serum activation of Akt is associated with tyrosine phosphorylation of Akt Homo sapiens

Protein Variants

Protein Variants Comment Organism
T474F 55% inhibition of Akt activation Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P31749
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein in SKOV3 ovarian carcinoma cells that exhibit high basal levels of Akt activity, Akt is tyrosine-phosphorylated in the basal state, and this phosphorylation is further enhanced by both pervanadate and insulin-like growth factor-1, Tyr474 is the site of tyrosine phosphorylation Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
cell culture SKOV3 ovarian carcinoma cell Homo sapiens
-
SKOV-3 cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
Akt protein kinase
-
 Homo sapiens
RAC-alpha serine/threonine kinase
-
 Homo sapiens