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Literature summary for 2.7.10.2 extracted from

  • Li, Y.; Wang, P.; Chen, C.; Ye, T.; Han, Y.; Hou, Y.; Liu, Y.; Gong, P.; Qin, M.; Zhao, Y.
    Discovery and rational design of 2-aminopyrimidine-based derivatives targeting Janus kinase 2 (JAK2) and FMS-like tyrosine kinase 3 (FLT3) (2020), Bioorg. Chem., 104, 104361 .
    View publication on PubMed
Search for more literature for 2.7.10.2

Inhibitors

Inhibitors Comment Organism Structure
1-(4-((5-methyl-2-((4-morpholinophenyl)amino)pyrimidin-4-yl) amino)piperidin-1-yl)ethan-1-one 100 nM, 70.5% inhibition. 28°C, pH not specified in the publication Homo sapiens
1-(4-(5-methyl-2-((4-morpholinophenyl)amino)pyrimidin-4-yl) piperazin-1-yl)ethan-1-one 100 nM, 66.2% inhibition. 28°C, pH not specified in the publication Homo sapiens
1-(4-(5-methyl-2-((4-morpholinophenyl)amino)pyrimidin-4-yl) piperazin-1-yl)pentane-1,4-dione 100 nM, 56.4% inhibition. 28°C, pH not specified in the publication Homo sapiens
1-(4-(5-methyl-2-((4-morpholinophenyl)amino)pyrimidin-4-yl) piperazin-1-yl)propan-1-one 100 nM, 73.4% inhibition. 28°C, pH not specified in the publication Homo sapiens
1-(4-acetylphenyl)-3-(1-(5-methyl-2-((4-morpholinophenyl) amino)pyrimidin-4-yl)azetidin-3-yl)urea 100 nM, 21.9% inhibition. 28°C, pH not specified in the publication Homo sapiens
1-(4-acetylphenyl)-3-(1-(5-methyl-2-((4-morpholinophenyl) amino)pyrimidin-4-yl)pyrrolidin-3-yl)urea 100 nM, 57.4% inhibition. 28°C, pH not specified in the publication Homo sapiens
2-(4-acetylphenyl)-1-(4-(2-((4-morpholinophenyl)amino)thieno[3,2-d]pyrimidin-4-yl)piperazin-1-yl)ethan-1-one 100 nM, 44% inhibition. 28°C, pH not specified in the publication Homo sapiens
4-(2-(4-(2-((4-morpholinophenyl)amino)thieno[3,2-d]pyrimidin-4-yl)piperazin-1-yl)-2-oxoethyl)benzonitrile 100 nM, 17.6% inhibition. 28°C, pH not specified in the publication Homo sapiens
4-(4-(cyclopropylsulfonyl)piperazin-1-yl)-5-methyl-N-(4-morpholinophenyl)pyrimidin-2-amine 100 nM, 76.2% inhibition. 28°C, pH not specified in the publication Homo sapiens
5-methyl-4-(4-(methylsulfonyl)piperazin-1-yl)-N-(4-morpholinophenyl)pyrimidin-2-amine 100 nM, 1.0% inhibition. 28°C, pH not specified in the publication Homo sapiens
8-(1-acetylpiperidin-4-yl)-2-((4-morpholinophenyl)amino)pteridin-7(8H)-one 100 nM, 3.5% inhibition. 28°C, pH not specified in the publication Homo sapiens
cyclopropyl(4-(5-methyl-2-((4-morpholinophenyl)amino)pyrimidin-4-yl)piperazin-1-yl)methanone 100 nM, 77.0% inhibition. 28°C, pH not specified in the publication Homo sapiens
N,N-dimethyl-4-(5-methyl-2-((4-morpholinophenyl)amino)pyrimidin-4-yl)piperazine-1-carboxamide 100 nM, 63.4% inhibition. 28°C, pH not specified in the publication Homo sapiens
N-(4-acetylphenyl)-1-(5-methyl-2-((4-morpholinophenyl) amino)pyrimidin-4-yl)piperidine-4-carboxamide 100 nM, 74.3% inhibition. 28°C, pH not specified in the publication Homo sapiens
N-(4-acetylphenyl)-3-((5-methyl-2-((4-morpholinophenyl) amino)pyrimidin-4-yl)amino)azetidine-1-carboxamide 100 nM, 8.1% inhibition. 28°C, pH not specified in the publication Homo sapiens
N-(4-acetylphenyl)-3-((5-methyl-2-((4-morpholinophenyl) amino)pyrimidin-4-yl)amino)pyrrolidine-1-carboxamide 100 nM, 69.3% inhibition. 28°C, pH not specified in the publication Homo sapiens
N-(4-acetylphenyl)-4-((5-methyl-2-((4-morpholinophenyl) amino)pyrimidin-4-yl)amino)piperidine-1-carboxamide 100 nM, 80.5% inhibition. 28°C, pH not specified in the publication Homo sapiens
N-(4-acetylphenyl)-4-(2-((4-morpholinophenyl)amino)-5-(trifluoromethyl)pyr-imidin-4-yl)piperazine-1-carboxamide 100 nM, 74.6% inhibition. 28°C, pH not specified in the publication Homo sapiens
N-(4-acetylphenyl)-4-(2-((4-morpholinophenyl)amino)-5-nitropyrimidin-4-yl)piperazine-1-carboxamide 100 nM, 68.4% inhibition. 28°C, pH not specified in the publication Homo sapiens
N-(4-acetylphenyl)-4-(2-((4-morpholinophenyl)amino)-7-oxopteridin-8(7H)-yl)piperidine-1-carboxamide 100 nM, 2.3% inhibition. 28°C, pH not specified in the publication Homo sapiens
N-(4-acetylphenyl)-4-(2-((4-morpholinophenyl)amino)quinazolin-4-yl)piperazine-1-carboxamide 100 nM, 3.2% inhibition. 28°C, pH not specified in the publication Homo sapiens
N-(4-acetylphenyl)-4-(5-amino-2-((4-morpholinophenyl)amino) pyrimidin-4-yl)piperazine-1-carboxamide 100 nM, 22.8% inhibition. 28°C, pH not specified in the publication Homo sapiens
N-(4-acetylphenyl)-4-(5-chloro-2-((4-morpholinophenyl)amino) pyrimidin-4-yl)piperazine-1-carboxamide 100 nM, 99.4% inhibition. 28°C, pH not specified in the publication Homo sapiens
N-(4-acetylphenyl)-4-(5-fluoro-2-((4-morpholinophenyl)amino) pyrimidin-4-yl)piperazine-1-carboxamide 100 nM, 93.5% inhibition. 28°C, pH not specified in the publication Homo sapiens
N-(4-acetylphenyl)-4-(5-methyl-2-((4-morpholinophenyl) amino)pyrimidin-4-yl)piperazine-1-sulfonamide 100 nM, 82.4 % inhibition. 28°C, pH not specified in the publication Homo sapiens
N-(4-acetylphenyl)-4-(5-methyl-2-((4-morpholinophenyl)amino)pyrimidin-4-yl)piperazine-1-carboxamide 2.9 nM, 81.8% inhibition. 28°C, pH not specified in the publication Homo sapiens
N-(4-acetylphenyl)-4-(6-methyl-2-((4-morpholinophenyl)amino)pyrimidin-4-yl)piperazine-1-carboxamide 100 nM, 15.6% inhibition. 28°C, pH not specified in the publication Homo sapiens
N-(4-acetylphenyl)-4-[2-[4-(morpholin-4-yl)anilino]pyrimidin-4-yl]piperazine-1-carboxamide 27 nM, 86.7% inhibition. 28°C, pH not specified in the publication Homo sapiens
N-(4-cyanophenyl)-1-(5-methyl-2-((4-morpholinophenyl) amino)pyrimidin-4-yl)piperidine-4-carboxamide 100 nM, 72.8% inhibition. 28°C, pH not specified in the publication Homo sapiens
N-(4-cyanophenyl)-4-(2-((4-morpholinophenyl)amino)quinazolin-4-yl)piperazine-1-carboxamide 100 nM, 9.7% inhibition. 28°C, pH not specified in the publication Homo sapiens
N-(4-cyanophenyl)-4-(5-methyl-2-((4-morpholinophenyl)amino)pyrimidin-4-yl)piperazine-1-carboxamide 100 nM, 88.5% inhibition. 28°C, pH not specified in the publication Homo sapiens
N-(4-cyanophenyl)-4-(6-methyl-2-((4-morpholinophenyl)amino)pyrimidin-4-yl)piperazine-1-carboxamide 100 nM, 8.9% inhibition. 28°C, pH not specified in the publication Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O60674
-
-

Synonyms

Synonyms Comment Organism
JAK2
-
 Homo sapiens
Janus kinase 2
-
 Homo sapiens