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Literature summary for 2.7.10.2 extracted from

  • Lin, Y.L.; Roux, B.
    Computational analysis of the binding specificity of Gleevec to Abl, c-Kit, Lck, and c-Src tyrosine kinases (2013), J. Am. Chem. Soc., 135, 14741-14753.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.10.2

Crystallization (Commentary)

Crystallization (Comment) Organism
in complex with gleevec Mus musculus
in complex with gleevec Gallus gallus
in complex with gleevec Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Gleevec also known as STI-571 or imatinib Gallus gallus
Gleevec also known as STI-571 or imatinib Homo sapiens
Gleevec also known as STI-571 or imatinib Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a [protein]-L-tyrosine Mus musculus
-
 ADP + a [protein]-L-tyrosine phosphate
-
 ?
ATP + a [protein]-L-tyrosine Gallus gallus
-
 ADP + a [protein]-L-tyrosine phosphate
-
 ?
ATP + a [protein]-L-tyrosine Homo sapiens
-
 ADP + a [protein]-L-tyrosine phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Gallus gallus P00523
-
-
Homo sapiens P06239
-
-
Mus musculus P00520
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a [protein]-L-tyrosine
-
 Mus musculus ADP + a [protein]-L-tyrosine phosphate
-
 ?
ATP + a [protein]-L-tyrosine
-
 Gallus gallus ADP + a [protein]-L-tyrosine phosphate
-
 ?
ATP + a [protein]-L-tyrosine
-
 Homo sapiens ADP + a [protein]-L-tyrosine phosphate
-
 ?

Synonyms

Synonyms Comment Organism
Abl
-
 Mus musculus
C-SRC
-
 Gallus gallus
Lck
-
 Homo sapiens