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Literature summary for 2.7.10.2 extracted from

  • Gelman, I.H.
    Androgen receptor activation in castration-recurrent prostate cancer: the role of Src-family and Ack1 tyrosine kinases (2014), Int. J. Biol. Sci., 10, 620-626.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.10.2

Inhibitors

Inhibitors Comment Organism Structure
4-(2,4-dichloro-5-methoxyanilino)-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile inhibitor of Src and Abl Homo sapiens
saracatinib inhibitor of Src and Abl Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [androgen receptor]-L-tyrosine Homo sapiens
-
 ADP + [androgen receptor]-L-tyrosine phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
prostate cancer cell
-
 Homo sapiens
-
prostate cancer cell line
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [androgen receptor]-L-tyrosine
-
 Homo sapiens ADP + [androgen receptor]-L-tyrosine phosphate
-
 ?

Synonyms

Synonyms Comment Organism
ACK1
-
 Homo sapiens
Lyn
-
 Homo sapiens
SFK
-
 Homo sapiens
Src
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function enzyme expression of specific SFK or Ack1 can drive the formation of prostate cancer or progression to castration-recurrent prostate cancer Homo sapiens