Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
neuron | primary culture of hippocampal neuron | Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
Lck | - |
Mus musculus |
lymphocyte-specific protein tyrosine kinase | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | specific pharmacological inhibition and genetic silencing indicate the involvement of isoform Lck in the regulation of neuritic outgrowth. Specific Lck inhibition also selectively impairs the long-term hippocampal synaptic plasticity without affecting spontaneous excitatory synaptic transmission or short-term synaptic potentiation and significantly alters hippocampus-dependent spatial learning and memory in vivo | Mus musculus |