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Literature summary for 2.7.10.2 extracted from

  • Lin, Q.; Wang, J.; Childress, C.; Yang, W.
    The activation mechanism of ACK1 (activated Cdc42-associated tyrosine kinase 1) (2012), Biochem. J., 445, 255-264.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
SW445P mutation causes constitutive activation Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q07912 ACK1
-

Synonyms

Synonyms Comment Organism
ACK1
-
Homo sapiens
activated Cdc42-associated tyrosine kinase 1
-
Homo sapiens
TNK2
-
Homo sapiens

General Information

General Information Comment Organism
physiological function interaction of the Src homology 3 domain SH3 with the epidermal growth factor receptor-binding domain in isoform ACK1 leads to auto-inhibition of the kinase activity. Release of this auto-inhibition is a key step for activation of ACK1. Mutation of the SH3 domain causes activation of ACK1, independent of cell adhesion. A region at the N-terminus of ACK1, Leu10-Leu14, is essential for cell adhesion-mediated activation. In the activation of ACK1 by epidermal growth factor receptor signalling, growth-factor-receptor-bound protein Grb2 mediates the interaction of ACK1 with epidermal growth factor receptor through binding to the epidermal growth factor receptor-binding domain and activates ACK1 by releasing the auto-inhibition Homo sapiens