Any feedback?
Literature summary for 2.7.10.2 extracted from
- The JAK kinases: not just another kinase drug discovery target (2008), Semin. Cell Dev. Biol., 19, 319-328.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (2E)-3-(6-bromopyridin-2-yl)-2-cyano-N-[(1S)-1-phenylethyl]prop-2-enamide | WP1066 | Homo sapiens |  |
| (2E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide | LS104 | Homo sapiens | |
| (2E,4E)-N-benzyl-2-cyano-5-(3,4-dihydroxyphenyl)penta-2,4-dienamide | AG490, potent JAK2 inhibitor | Homo sapiens | |
| 2-tert-butyl-9-fluoro-3,6-dihydro-7H-benz[h]-imidaz[4,5-f]isoquinoline-7-one | potent pan-JAK inhibitor | Homo sapiens | |
| 3-[(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]-3-oxopropanenitrile | CP-690,550 JAK3-specific inhibitor | Homo sapiens | |
| AG490 | potent JAK2 inhibitor | Homo sapiens | |
| CP-690,550 | JAK3-specific inhibitor | Homo sapiens | |
| LS104 | - |
Homo sapiens | |
| N-tert-butyl-3-([5-methyl-2-[(4-piperazin-1-ylphenyl)amino]pyrimidin-4-yl]amino)benzenesulfonamide | TG101209 | Homo sapiens | |
| N-tert-butyl-3-[(5-methyl-2-[[4-(2-pyrrolidin-1-ylethoxy)phenyl]amino]pyrimidin-4-yl)amino]benzenesulfonamide | TG101348, JAK2-specific inhibitor | Homo sapiens | |
| TG101209 | - |
Homo sapiens | |
| TG101348 | JAK2-specific inhibitor | Homo sapiens | |
| WP1066 | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + a [protein]-L-tyrosine | Homo sapiens | - |
ADP + a [protein]-L-tyrosine phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + a [protein]-L-tyrosine | - |
Homo sapiens | ADP + a [protein]-L-tyrosine phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| JAK2 | - |
Homo sapiens |
| Jak3 | - |
Homo sapiens |
| Janus kinase | - |
Homo sapiens |
| just another kinase | - |
Homo sapiens |
| PTK | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
