Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | SH2-Bb and dimerized receptors synergistically promote Jak2 trans-activation in the context of intracellular signaling, SH2-B and receptor dimers constitute a bipolar clamp that stabilizes the active configuration of two Jak2 molecules in the same macro-complex | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a [protein]-L-tyrosine | Homo sapiens | - |
ADP + a [protein]-L-tyrosine phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | Jak2 can be phosphorylated on Y1 and Y2 only when two Jak2 molecules are associated with the same complex (receptor or/and SH2-Bbeta mediated). Once Y2 is phosphorylated, the catalytic efficiency of that Jak2 molecule increases substantially | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a [protein]-L-tyrosine | - |
Homo sapiens | ADP + a [protein]-L-tyrosine phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
JAK2 | - |
Homo sapiens |
Janus kinase | - |
Homo sapiens |
non-receptor protein tyrosine kinase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |