Literature summary for 2.7.10.2 extracted from

Li, J.; Favata, M.; Kelley, J.A.; Caulder, E.; Thomas, B.; Wen, X.; Sparks, R.B.; Arvanitis, A.; Rogers, J.D.; Combs, A.P.; Vaddi, K.; Solomon, K.A.; Scherle, P.A.; Newton, R.; Fridman, J.S.
INCB16562, a JAK1/2 selective inhibitor, is efficacious against multiple myeloma cells and reverses the protective effects of cytokine and stromal cell support (2010), Neoplasia, 12, 28-38.

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Inhibitors

Inhibitors	Comment	Organism	Structure
INCB16562	selective, and orally bioavailable small-molecule inhibitor of JAK1 and JAK2 markedly selective over JAK3	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
INA-6 cell	-	Homo sapiens	-
MM1-S cell	-	Homo sapiens	-
myeloma cell	-	Homo sapiens	-
NCI-H929 cell	-	Homo sapiens	-
plasma cell	primary CD138+ plasma cell	Homo sapiens	-
RPMI-8226 cell	-	Homo sapiens	-
TF-1 BCR-ABL cell	-	Homo sapiens	-
TF-1 cell	-	Homo sapiens	-
U-266 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + STAT3	-	Homo sapiens	ADP + phospho-L-tyrosinyl-STAT3	-	?

Synonyms

Synonyms	Comment	Organism
Jak1	-	Homo sapiens
JAK2	-	Homo sapiens
Jak3	-	Homo sapiens
Janus kinase	-	Homo sapiens
Tyk2	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.00000025	-	JAK2	Homo sapiens	INCB16562
0.0000022	-	JAK1	Homo sapiens	INCB16562
0.0000027	-	TYK2	Homo sapiens	INCB16562
0.0000101	-	JAK3	Homo sapiens	INCB16562

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Release 2023.1 (January 2023)