Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.10.2 extracted from

  • Lee, W.H.; Liu, F.H.; Lin, J.Y.; Huang, S.Y.; Lin, H.; Liao, W.J.; Huang, H.M.
    JAK pathway induction of c-Myc critical to IL-5 stimulation of cell proliferation and inhibition of apoptosis (2009), J. Cell. Biochem., 106, 929-936.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
interleukin 5 activates Janus kinases JAK1 and JAK2 Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Ba/F3 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
AG490
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a [protein]-L-tyrosine Homo sapiens
-
ADP + a [protein]-L-tyrosine phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a [protein]-L-tyrosine
-
Homo sapiens ADP + a [protein]-L-tyrosine phosphate
-
?

Synonyms

Synonyms Comment Organism
Jak1
-
Homo sapiens
JAK2
-
Homo sapiens
Janus kinase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens

General Information

General Information Comment Organism
physiological function JAK1 and JAK2 activate c-Myc promoter in interleukin 5 signaling Homo sapiens