Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | nerve injury induces the activation of Src family kinases, Lyn is the predominant kinase | Mus musculus | |
additional information | nerve injury induces the activation of Src family kinases, Lyn is the predominant kinase | Rattus norvegicus |
Application | Comment | Organism |
---|---|---|
medicine | Lyn is a key kinase in the molecular machineries mediating the P2X4R upregulation in microglia, and thereby, in neuropathic pain | Mus musculus |
medicine | Lyn is a key kinase in the molecular machineries mediating the P2X4R upregulation in microglia, and thereby, in neuropathic pain | Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
53000 | - |
alternative splicing variant, identified by SDS-PAGE and Western blot analysis | Mus musculus |
53000 | - |
alternative splicing variant, identified by SDS-PAGE and Western blot analysis | Rattus norvegicus |
56000 | - |
identified by SDS-PAGE and Western blot analysis | Mus musculus |
56000 | - |
identified by SDS-PAGE and Western blot analysis | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [protein]-L-tyrosine | Mus musculus | - |
ADP + [protein]-L-tyrosine phosphate | - |
? | |
ATP + [protein]-L-tyrosine | Rattus norvegicus | - |
ADP + [protein]-L-tyrosine phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P25911 | - |
- |
Rattus norvegicus | Q07014 | male Wistar rats | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | full activation requires autophosphorylation at a tyrosine residue located in the kinase domain | Mus musculus |
phosphoprotein | full activation requires autophosphorylation at a tyrosine residue located in the kinase domain | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
brain | - |
Rattus norvegicus | - |
microglia | spinal microglia | Mus musculus | - |
microglia | spinal microglia | Rattus norvegicus | - |
neuron | - |
Mus musculus | - |
neuron | - |
Rattus norvegicus | - |
spinal nerve | - |
Mus musculus | - |
spinal nerve | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [protein]-L-tyrosine | - |
Mus musculus | ADP + [protein]-L-tyrosine phosphate | - |
? | |
ATP + [protein]-L-tyrosine | - |
Rattus norvegicus | ADP + [protein]-L-tyrosine phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Lyn tyrosine kinase | - |
Mus musculus |
Lyn tyrosine kinase | - |
Rattus norvegicus |