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Literature summary for 2.7.10.2 extracted from

  • Perez de Diego, R.; Lopez-Granados, E.; Rivera, J.; Ferreira, A.; Fontan, G.; Bravo, J.; Garcia Rodriguez, M.C.; Bolland, S.
    Naturally occurring Brutons tyrosine kinase mutations have no dominant negative effect in an X-linked agammaglobulinaemia cellular model (2008), Clin. Exp. Immunol., 152, 33-38.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.10.2

Activating Compound

Activating Compound Comment Organism Structure
Lyn kinase as part of the activation process Lyn phosphorylates Btk in Tyr551, which is subsequently autophosphorylated in Tyr223 Homo sapiens

Application

Application Comment Organism
medicine X-linked agammaglobulinaemia is a primary immune deficiency characterized by lack of circulating mature B cells, hypogammaglobulinaemia and recurrent infections because of a mutations in the Btk gene Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
for transfection of DT40 lymphoma cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
F540S mutant, shows absence of Btk phosphorylation on Tyr223 Homo sapiens
K374N mutant, residual kinase activity is present Homo sapiens
K430E mutant, shows absence of Btk phosphorylation on Tyr223 Homo sapiens
R288W mutant, residual kinase activity is present Homo sapiens
R28C mutant Homo sapiens
R544G mutant, residual kinase activity is present Homo sapiens
R544S mutant, residual kinase activity is present Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [protein]-L-tyrosine Homo sapiens
-
 ADP + [protein]-L-tyrosine phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q06187
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [protein]-L-tyrosine
-
 Homo sapiens ADP + [protein]-L-tyrosine phosphate
-
 ?

Synonyms

Synonyms Comment Organism
Brutons tyrosine kinase
-
 Homo sapiens
Btk
-
 Homo sapiens