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Literature summary for 2.7.10.2 extracted from

  • Kannan, S.; Audet, A.; Knittel, J.; Mullegama, S.; Gao, G.F.; Wu, M.
    Src kinase Lyn is crucial for Pseudomonas aeruginosa internalization into lung cells (2006), Eur. J. Immunol., 36, 1739-1752.
    View publication on PubMed
Search for more literature for 2.7.10.2

Protein Variants

Protein Variants Comment Organism
additional information enzyme deletion or mutation, e.g. in a dominant negative mutant or in Lyn-deficient bone marrow-derived mast cells, prevents internalization of the organism into host cells and affects induction of inflammatory cytokines and apoptosis Pseudomonas aeruginosa

Inhibitors

Inhibitors Comment Organism Structure
4-amino-5-(4-chlorophenyl)-7-(tert-butyl)pyrazolo[3,4-d] pyrimidine enzyme inhibition prevents internalization of the organism into host cells Pseudomonas aeruginosa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Pseudomonas aeruginosa Lyn is an important B cell signaling kinase of the Src tyrosine kinase family with a broad range of functions from cytoskeletal changes to induction of apoptosis, Lyn and and its interaction with rafts and TLR2 are involved in the initial stages of Pseudomonas aeruginosa interaction with host cells and invasion of an alveolar epithelial cell line, primary lung cells, and rat lungs by Pseudomonas aeruginosa, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa
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 strain PAO1 and strain ATCC 27853
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Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein Lyn is activated by phosphorylation Pseudomonas aeruginosa

Source Tissue

Source Tissue Comment Organism Textmining

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
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 infection effectivity of A-549 cells by wild-type and mutant strains, overview Pseudomonas aeruginosa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Lyn is an important B cell signaling kinase of the Src tyrosine kinase family with a broad range of functions from cytoskeletal changes to induction of apoptosis, Lyn and and its interaction with rafts and TLR2 are involved in the initial stages of Pseudomonas aeruginosa interaction with host cells and invasion of an alveolar epithelial cell line, primary lung cells, and rat lungs by Pseudomonas aeruginosa, overview Pseudomonas aeruginosa ?
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 ?

Synonyms

Synonyms Comment Organism
Lyn
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 Pseudomonas aeruginosa
More the enzyme belongs to the Src tyrosine kinase family Pseudomonas aeruginosa
Src kinase
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 Pseudomonas aeruginosa