Literature summary for 2.7.10.2 extracted from

Lacour, S.; Doublet, P.; Obadia, B.; Cozzone, A.J.; Grangeasse, C.
A novel role for protein-tyrosine kinase Etk from Escherichia coli K-12 related to polymyxin resistance (2006), Res. Microbiol., 157, 637-641.

Search for more literature for 2.7.10.2

Cloned(Commentary)

Cloned (Comment)	Organism
genes wzc and etk, expression of wild-type and mutant enzymes in strain W3110	Escherichia coli K-12

Protein Variants

Protein Variants	Comment	Organism
additional information	gene replacement knockout mutations of genes wzc and etk in strain W3110 using a one-step-inactivation PCR-based method, revealing that Wzc is not essential, but Etk is essential for polymyxin resistance, overview	Escherichia coli K-12

Metals/Ions

Metals/Ions	Comment	Organism	Structure
K+	-	Escherichia coli K-12
Mg2+	-	Escherichia coli K-12
additional information	no requirement for Fe2+	Escherichia coli K-12

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
81000	-	x * 81000, Wzc and Etk, SDS-PAGE	Escherichia coli K-12

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Escherichia coli K-12	Etk is essential for polymyxin resistance, while Wzc is not	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli K-12	-	genes wzc and etk	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	Etk is essential for polymyxin resistance, while Wzc is not	Escherichia coli K-12	?	-	?

Subunits

Subunits	Comment	Organism
?	x * 81000, Wzc and Etk, SDS-PAGE	Escherichia coli K-12

Synonyms

Synonyms	Comment	Organism
ETK	-	Escherichia coli K-12
protein-tyrosine kinase	-	Escherichia coli K-12
Wzc	-	Escherichia coli K-12

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Escherichia coli K-12

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.7	-	assay at	Escherichia coli K-12

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Escherichia coli K-12

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Release 2023.1 (January 2023)