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Literature summary for 2.7.10.2 extracted from
- Signaling by Toll-like receptors -8 and -9 requires Brutons tyrosine kinase (2007), J. Biol. Chem., 282, 36953-36960.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| transient co-expression of Btk and Toll-like receptors TLR-8 and TLR-9 in HEK-293 cells, interaction study, overview | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Homo sapiens | 5737 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | Toll-like receptors TLR-8 and TLR-9 require activation/phosphorylation by Btk for acting incell signaling, overview, enzyme deficiency is involved in development of male immune disorder X-linked agammaglobulineamia, XLA | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | the PH domain is important in the process of Btk activation which localises Btk to the membrane through its interaction with phosphatidylinositol 3,4,5-triphosphate | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| B-cell lymphoma cell | - |
Homo sapiens | - |
| monocyte | - |
Homo sapiens | - |
| THP-1 cell | untreated or stimulated by R848 or CpG-DNA | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Toll-like receptors TLR-8 and TLR-9 require activation/phosphorylation by Btk for acting incell signaling, overview, enzyme deficiency is involved in development of male immune disorder X-linked agammaglobulineamia, XLA | Homo sapiens | ? | - |
? | |
| additional information | Btk can interact with the TIR domains of Toll-like receptors TLR-8 and TLR-9 | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Brutons tyrosine kinase | - |
Homo sapiens |
| Btk | - |
Homo sapiens |
| More | Btk is a member of the Tec family of protein kinases | Homo sapiens |
| non-receptor tyrosine kinase | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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