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Literature summary for 2.7.10.2 extracted from

  • Shi, Y.; Tohyama, Y.; Kadono, T.; He, J.; Shahjahan Miah, S.M.; Hazama, R.; Tanaka, C.; Tohyama, K.; Yamamura, H.
    Protein-tyrosine kinase Syk is required for pathogen engulfment in complement-mediated phagocytosis (2006), Blood, 107, 4554-4562.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information Syk is activated by phosphorylation Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information expression of siRNA of Syk or the domainant-negative Syk mutat DN-Syk in HL-60 cells leads to inhibition of phagocytosis, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens protein-tyrosine kinase Syk plays a central role in Fcgamma receptor-mediated phagocytosis in the adaptive immune system, and is required for pathogen engulfment in complement-mediated phagocytosis ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein Syk is activated by phosphorylation Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HL-60 cell macrophage-like differentiated Homo sapiens
-
macrophage
-
Homo sapiens
-
monocyte primary Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information protein-tyrosine kinase Syk plays a central role in Fcgamma receptor-mediated phagocytosis in the adaptive immune system, and is required for pathogen engulfment in complement-mediated phagocytosis Homo sapiens ?
-
?
additional information Syk affects actin dynamics around the C3bi-mediated phagosomes Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
Protein-tyrosine kinase Syk
-
Homo sapiens
Syk
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens