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Literature summary for 2.7.10.2 extracted from
- Syk is required for monocyte/macrophage chemotaxis to CX3CL1 (Fractalkine) (2005), J. Immunol., 175, 3737-3745.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| CX3CL1 | i.e. fractalkine, only member of the delta subclass of chemokines, induces Syk activity in cytoskeletal remodeling | Mus musculus |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| retroviral expression in 293T cells prior to infection of RAW cells for stable Syk expression | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| piceatannol | Syk inhibitor in vitro and in vivo | Mus musculus |  |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 75000 | - |
x * 75000, about, Syk, SDS-PAGE | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | CX3CL1, i.e. fractalkine, only member of the delta subclass of chemokines, triggers PTK Syk activity in monocytes/macrophages localized in F-actin-enriched cell protrusions, which are formed due to CX3CL1 treatment and subsequent increase in F-actin, Syk deficiency results in strong impairment of RAW cell migration to CX3CL1, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| bone marrow | - |
Mus musculus | - |
| macrophage | from bone marrow | Mus musculus | - |
| monocyte | - |
Mus musculus | - |
| RAW/LR5 cell | derived from monocyte/macrophage cell line RAW 264.7 | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | CX3CL1, i.e. fractalkine, only member of the delta subclass of chemokines, triggers PTK Syk activity in monocytes/macrophages localized in F-actin-enriched cell protrusions, which are formed due to CX3CL1 treatment and subsequent increase in F-actin, Syk deficiency results in strong impairment of RAW cell migration to CX3CL1, overview | Mus musculus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 75000, about, Syk, SDS-PAGE | Mus musculus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Protein tyrosine kinase | - |
Mus musculus |
| Syk | - |
Mus musculus |
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