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Literature summary for 2.7.10.2 extracted from

  • Du, X.L.; Gao, Z.; Lau, C.P.; Chiu, S.W.; Tse, H.F.; Baumgarten, C.M.; Li, G.R.
    Differential effects of tyrosine kinase inhibitors on volume-sensitive chloride current in human atrial myocytes: evidence for dual regulation by Src and EGFR kinases (2004), J. Gen. Physiol., 123, 427-439.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
genistein broad-spectrum PTK inhibitor, increases volume-sensitive chloride current in atrial myocytes, is antagonized by pretreatment with VO43- Homo sapiens
tyrphostin A23 broad-spectrum PTK inhibitor, slight inhibition of Src Homo sapiens
tyrphostin A25 broad-spectrum PTK inhibitor, slight inhibition of Src Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme is regulated in balance with protein tyrosine phosphatase, complex regulation mechanism, overview, the enzyme has decreasing effect, opposing to receptor protein tyrosine kinase EGFR, on volume-sensitive chloride current in atrial myocytes, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
atrium
-
Homo sapiens
-
myocyte atrial Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme is regulated in balance with protein tyrosine phosphatase, complex regulation mechanism, overview, the enzyme has decreasing effect, opposing to receptor protein tyrosine kinase EGFR, on volume-sensitive chloride current in atrial myocytes, overview Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
Protein tyrosine kinase
-
Homo sapiens
PTK
-
Homo sapiens
Src
-
Homo sapiens
Src tyrosine kinase
-
Homo sapiens