Cloned (Comment) | Organism |
---|---|
expression of activated allele of Fes tyrosine kinase, Fesact, encoded by c-fps/es proto-oncogene, in factor-dependent 32D cells preventing their apoptotic death after interleukin-3 removal followd by granulocytic differentiation, factor dependency remains for proliferation, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | Fes tyrosine kinase promotes survival and terminal granulocyte differentiation of factor-dependent myeloid progenitors (32D) and activates lineage-specific transcription factors, e.g. CCAAT/enhancer-binding protein-alpha and STAT3, down-regulation of macrophage marker F4/80 | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Fes tyrosine kinase promotes survival and terminal granulocyte differentiation of factor-dependent myeloid progenitors (32D) and activates lineage-specific transcription factors, e.g. CCAAT/enhancer-binding protein-alpha and STAT3, down-regulation of macrophage marker F4/80 | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Fes | - |
Homo sapiens |
Fes tyrosine kinase | - |
Homo sapiens |