Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.10.2 extracted from

  • Backlund, M.; Ingelman-Sundberg, M.
    Regulation of aryl hydrocarbon receptor signal transduction by protein tyrosine kinases (2005), Cell. Signal., 17, 39-48.
    View publication on PubMed
Search for more literature for 2.7.10.2

Inhibitors

Inhibitors Comment Organism Structure
4-amino-5-(4-chlorophenyl)-7-(tert-butyl)pyrazolo[3,4-d] pyrimidine i.e. pp2, inhibits Src family PTKs Homo sapiens
4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo[3,4-d] pyrimidine i.e. pp1, inhibits Src family PTKs Homo sapiens
additional information daidzein is no inhibitor of PTKs, no direct Src kinase inhibition by tyrphostin AG17, tyrphosptin AG879 and genistein Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Homo sapiens
Mn2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [aryl hydrocarbon receptor]-L-tyrosine Homo sapiens Src tyrosine kinases are involved in a signaling transduction pathway activating aryl hydrocarbon receptor AhR-mediated signalling by omeprazole or 2,3,7,8-tetrachlorodibenzo-4-dioxin TCDD ligand-binding, AhR phosphorylation at Tyr320, the omeprazole-dependent mechanism probably involves S318 and K316 ADP + [aryl hydrocarbon receptor]-L-tyrosine phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
 Homo sapiens
-
hepatoma cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + KVEKIGEGTYGVVYK synthetic peptide substrate Homo sapiens ADP + ?
-
 ?
ATP + [aryl hydrocarbon receptor]-L-tyrosine Src tyrosine kinases are involved in a signaling transduction pathway activating aryl hydrocarbon receptor AhR-mediated signalling by omeprazole or 2,3,7,8-tetrachlorodibenzo-4-dioxin TCDD ligand-binding, AhR phosphorylation at Tyr320, the omeprazole-dependent mechanism probably involves S318 and K316 Homo sapiens ADP + [aryl hydrocarbon receptor]-L-tyrosine phosphate
-
 ?
ATP + [aryl hydrocarbon receptor]-L-tyrosine in vivo assay utilizing Hep-G2 cells or H4IIE cells expressing AhR and Src kinase Homo sapiens ADP + [aryl hydrocarbon receptor]-L-tyrosine phosphate
-
 ?

Synonyms

Synonyms Comment Organism
C-SRC kinase
-
 Homo sapiens
Protein tyrosine kinase
-
 Homo sapiens
PTK
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
 assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens