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Literature summary for 2.7.10.2 extracted from

  • Adams, J.A.
    Kinetic and catalytic mechanisms of protein kinases (2001), Chem. Rev., 101, 2271-2290.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
-
eukaryota

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information c-Src, Csk: random kinetic mechanism, reaction kinetic can be influenced by the sort of substrate, high affinity for ADP eukaryota

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
eukaryota
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Cd2+ can partially substitue Mg2+ eukaryota
Co2+ can partially substitue Mg2+ eukaryota
Mg2+ dependent on, Mg2+ is the physiologic metal ion, other divalent cations are able to support nucleotide binding, but only Mn2+, Co2+, and Cd2+ can substitute Mg2+ in supporting the catalytic activity eukaryota
Mn2+ can partially substitue Mg2+ eukaryota

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a protein eukaryota
-
ADP + a phosphoprotein
-
?

Organism

Organism UniProt Comment Textmining
eukaryota
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein regulation by phosphorylation of the activation loop, decreases ATP binding and substrate binding, enhances the phosphotransfer rate eukaryota

Reaction

Reaction Comment Organism Reaction ID
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate reaction mechanism eukaryota

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a protein
-
eukaryota ADP + a phosphoprotein
-
?
ATP + a protein PhK phosphorylates e.g. the protein substrate GPb, v-Fps phosphorylates e.g. the peptide substrate EAEIYEAEI, Csk phosphorylates e.g. the substrate poly-Glu4-Tyr eukaryota ADP + a phosphoprotein
-
?
additional information poor activity on free amino acids, consensus sequence of c-Src is E-EIYE/G-XF, that of v-Fps is E-IYE-XI/V, and that of Csk is IYM-F-F-F, specificity overview eukaryota ?
-
?

Subunits

Subunits Comment Organism
More the enzyme consists of a kinase core and 2 noncatalytic portions SH2 and SH3 eukaryota

Synonyms

Synonyms Comment Organism
C-SRC
-
eukaryota
C-terminal Src kinase
-
eukaryota
cellular form of the transforming agent of Rous sarcoma virus
-
eukaryota
Csk
-
eukaryota
transforming agent of Fujinami sarcoma virus
-
eukaryota
v-Fps
-
eukaryota

Cofactor

Cofactor Comment Organism Structure
ATP dependent on eukaryota