Crystallization (Comment) | Organism |
---|---|
- |
eukaryota |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | c-Src, Csk: random kinetic mechanism, reaction kinetic can be influenced by the sort of substrate, high affinity for ADP | eukaryota |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
soluble | - |
eukaryota | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Cd2+ | can partially substitue Mg2+ | eukaryota | |
Co2+ | can partially substitue Mg2+ | eukaryota | |
Mg2+ | dependent on, Mg2+ is the physiologic metal ion, other divalent cations are able to support nucleotide binding, but only Mn2+, Co2+, and Cd2+ can substitute Mg2+ in supporting the catalytic activity | eukaryota | |
Mn2+ | can partially substitue Mg2+ | eukaryota |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a protein | eukaryota | - |
ADP + a phosphoprotein | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
eukaryota | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | regulation by phosphorylation of the activation loop, decreases ATP binding and substrate binding, enhances the phosphotransfer rate | eukaryota |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate | reaction mechanism | eukaryota |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a protein | - |
eukaryota | ADP + a phosphoprotein | - |
? | |
ATP + a protein | PhK phosphorylates e.g. the protein substrate GPb, v-Fps phosphorylates e.g. the peptide substrate EAEIYEAEI, Csk phosphorylates e.g. the substrate poly-Glu4-Tyr | eukaryota | ADP + a phosphoprotein | - |
? | |
additional information | poor activity on free amino acids, consensus sequence of c-Src is E-EIYE/G-XF, that of v-Fps is E-IYE-XI/V, and that of Csk is IYM-F-F-F, specificity overview | eukaryota | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | the enzyme consists of a kinase core and 2 noncatalytic portions SH2 and SH3 | eukaryota |
Synonyms | Comment | Organism |
---|---|---|
C-SRC | - |
eukaryota |
C-terminal Src kinase | - |
eukaryota |
cellular form of the transforming agent of Rous sarcoma virus | - |
eukaryota |
Csk | - |
eukaryota |
transforming agent of Fujinami sarcoma virus | - |
eukaryota |
v-Fps | - |
eukaryota |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | dependent on | eukaryota |