Literature summary for 2.7.1.91 extracted from

Imbert, C.; Montfort, A.; Fraisse, M.; Marcheteau, E.; Gilhodes, J.; Martin, E.; Bertrand, F.; Marcellin, M.; Burlet-Schiltz, O.; Peredo, A.G.; Garcia, V.; Carpentier, S.; Tartare-Deckert, S.; Brousset, P.; Rochaix, P.; Puisset, F.; Filleron, T.; Meyer, N.; Lamant, L.; Levade, T.; Segui, B.; Andrieu-Abadie, N.; Colacios, C.
Resistance of melanoma to immune checkpoint inhibitors is overcome by targeting the sphingosine kinase-1 (2020), Nat. Commun., 11, 437 .

Application

Application	Comment	Organism
medicine	sphingosine kinase-1 expression inversely correlates with survival after immune checkpoint inhibitor (ICI) therapy in melanoma tumors. Downregulation of sphingosine kinase-1 improves the efficacy of ICI therapy in various cancer models	Homo sapiens

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + sphingosine	Homo sapiens	-	ADP + sphingosine 1-phosphate	-	?

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9NYA1	-	-

Source Tissue	Comment	Organism	Textmining
melanoma cell	-	Homo sapiens	-

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + sphingosine	-	Homo sapiens	ADP + sphingosine 1-phosphate	-	?

Organism	Comment	Expression
Homo sapiens	sphingosine kinase-1 transcript levels are higher in human primary melanomas as compared to nevi	up

General Information	Comment	Organism
malfunction	sphingosine kinase-1 silencing decreases the expression of various immunosuppressive factors in the tumor microenvironment to limit regulatory T cell infiltration	Homo sapiens
physiological function	sphingosine kinase-1 is a key regulator of anti-tumor immunity. Increased expression of the enzyme in tumor cells is significantly associated with shorter survival in metastatic melanoma patients treated with anti-programmed cell death protein-1	Homo sapiens