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Literature summary for 2.7.1.91 extracted from

  • Worrell, B.L.; Brown, A.M.; Santos, W.L.; Bevan, D.R.
    In silico characterization of structural distinctions between isoforms of human and mouse sphingosine kinases for accelerating drug discovery (2019), J. Chem. Inf. Model., 59, 2339-2351 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
(R)-FTY720-OMe isoform SphK2-selective inhibitor Homo sapiens
(R)-FTY720-OMe isoform SphK2-selective inhibitor Mus musculus
Amgen 82
-
Homo sapiens
Amgen 82
-
Mus musculus
K145 i.e. (5E)-3-(2-aminoethyl)-5-[3-(4-butoxyphenyl)propylidene]-1,3-thiazolidine-2,4-dione, isoform SphK2-selective inhibitor Homo sapiens
K145 i.e. (5E)-3-(2-aminoethyl)-5-[3-(4-butoxyphenyl)propylidene]-1,3-thiazolidine-2,4-dione, isoform SphK2-selective inhibitor Mus musculus
PF-543 isoform SphK1-selective inhibitor Homo sapiens
PF-543 isoform SphK1-selective inhibitor Mus musculus
SKI-II i.e. 4-[[4-(4-chlorophenyl)thiazol-2-yl]amino]phenol, isoform SphK1-selective inhibitor Homo sapiens
SKI-II i.e. 4-[[4-(4-chlorophenyl)thiazol-2-yl]amino]phenol; i.e. 4-[[4-(4-chlorophenyl)thiazol-2-yl]amino]phenol Mus musculus
SLC5081308 isoform SphK2-selective inhibitor Homo sapiens
SLC5081308 isoform SphK2-selective inhibitor Mus musculus
SLC5091592 isoform SphK2-selective inhibitor Homo sapiens
SLC5091592 isoform SphK2-selective inhibitor Mus musculus
SLC5111312
-
Homo sapiens
SLC5111312
-
Mus musculus
SLP7111228 isoform SphK1-selective inhibitor Homo sapiens
SLP7111228 isoform SphK1-selective inhibitor Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Mus musculus 5737
-
cytoplasm isoform SphK1 Homo sapiens 5737
-
nucleus
-
Mus musculus 5634
-
nucleus isoform SphK2 Homo sapiens 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens
Mg2+ required Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + sphingosine Homo sapiens
-
ADP + sphingosine 1-phosphate
-
?
ATP + sphingosine Mus musculus
-
ADP + sphingosine 1-phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NRA0
-
-
Homo sapiens Q9NYA1 isoform SphK1
-
Mus musculus Q8CI15
-
-
Mus musculus Q9JIA7
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + sphingosine
-
Homo sapiens ADP + sphingosine 1-phosphate
-
?
ATP + sphingosine
-
Mus musculus ADP + sphingosine 1-phosphate
-
?

Synonyms

Synonyms Comment Organism
sphingosine kinase 1
-
Homo sapiens
sphingosine kinase 1
-
Mus musculus
sphingosine kinase 2
-
Homo sapiens
sphingosine kinase 2
-
Mus musculus
SPHK1 isoform Homo sapiens
SPHK1 isoform Mus musculus
SPHK2 isoform Homo sapiens
SPHK2 isoform Mus musculus