Literature summary for 2.7.1.91 extracted from

Zhang, M.; Zhou, D.; Ouyang, Z.; Yu, M.; Jiang, Y.
Sphingosine kinase 1 promotes cerebral ischemia-reperfusion injury through inducing ER stress and activating the NF-kappaB signaling pathway (2020), J. Cell. Physiol., 235, 6605-6614 .

Search for more literature for 2.7.1.91

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q8CI15	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
Neuro-2a cell	-	Mus musculus	-
neuroblastoma cell	-	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
sphingosine kinase 1	-	Mus musculus
SPHK1	isoform	Mus musculus

Expression

Organism	Comment	Expression
Mus musculus	isoform SPHK1 expression is significantly elevated after exposure to hydrogen peroxide	up

General Information

General Information	Comment	Organism
malfunction	isoform SPHK1 deletion reduces endoplasm reticulum stress and alleviates inflammation response in hydrogen peroxide-treated cells	Mus musculus
physiological function	isofom SPHK1 upregulation, induced by hydrogen peroxide, is responsible for cerebral IR injury through inducing endoplasm reticulum stress and inflammation response in a manner working through the nuclear factor-kappaB signaling pathway	Mus musculus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)