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Literature summary for 2.7.1.91 extracted from
- Sphingosine kinase 1/sphingosine-1-phosphate regulates the expression of interleukin-17A in activated microglia in cerebral ischemia/reperfusion (2016), Inflamm. Res., 65, 551-562 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| PF-543 | - |
Rattus norvegicus |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + sphingosine | Rattus norvegicus | - |
ADP + sphingosine 1-phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | Q91V26 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| microglia | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + sphingosine | - |
Rattus norvegicus | ADP + sphingosine 1-phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| sphingosine kinase 1 | - |
Rattus norvegicus |
| SPHK1 | isoform | Rattus norvegicus |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Rattus norvegicus | enzyme expression is increased in microglia subjected to oxygen-glucose deprivation | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the enzyme regulates the expression of interleukin-17A in activated microglia in cerebral ischemia/reperfusion | Rattus norvegicus |
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Release 2023.1 (January 2023)
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