Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2S)-1-(3-dodecylbenzoyl)pyrrolidine-2-carboximidamide | - |
Homo sapiens | |
(2S)-1-(4-[4-[3-(2-cyclohexylethyl)phenyl]-1,3-oxazol-2-yl]benzoyl)pyrrolidine-2-carboximidamide | - |
Homo sapiens | |
(2S)-1-[3-[7-(cyclohexylmethoxy)heptyl]benzoyl]pyrrolidine-2-carboximidamide | - |
Homo sapiens | |
1-carbamimidoyl-N-(3-dodecylphenyl)cyclopropane-1-carboxamide | - |
Homo sapiens | |
1-[3-(3-decylphenyl)-1,2,4-oxadiazol-5-yl]cyclopropane-1-carboximidamide | - |
Homo sapiens | |
1-[3-(3-dodecylphenyl)-1,2,4-oxadiazol-5-yl]cyclopropane-1-carboximidamide | - |
Homo sapiens | |
1-[3-(3-tridecylphenyl)-1,2,4-oxadiazol-5-yl]cyclopropane-1-carboximidamide | - |
Homo sapiens | |
1-[3-(3-undecylphenyl)-1,2,4-oxadiazol-5-yl]cyclopropane-1-carboximidamide | - |
Homo sapiens | |
1-[3-(4-decylphenyl)-1,2,4-oxadiazol-5-yl]cyclopropane-1-carboximidamide | - |
Homo sapiens | |
1-[3-(4-dodecylphenyl)-1,2,4-oxadiazol-5-yl]cyclopropane-1-carboximidamide | - |
Homo sapiens | |
1-[3-(4-tridecylphenyl)-1,2,4-oxadiazol-5-yl]cyclopropane-1-carboximidamide | - |
Homo sapiens | |
1-[3-(4-undecylphenyl)-1,2,4-oxadiazol-5-yl]cyclopropane-1-carboximidamide | - |
Homo sapiens | |
1-[5-(3-dodecylphenyl)-1,2,4-oxadiazol-3-yl]cyclopropane-1-carboximidamide | - |
Homo sapiens | |
1-[5-(3-dodecylphenyl)-1,3,4-oxadiazol-2-yl]cyclopropane-1-carboximidamide | - |
Homo sapiens | |
1-[5-(4-dodecylphenyl)-1,2,4-oxadiazol-3-yl]cyclopropane-1-carboximidamide | - |
Homo sapiens | |
1-[5-(4-dodecylphenyl)-1,3,4-oxadiazol-2-yl]cyclopropane-1-carboximidamide | - |
Homo sapiens | |
N-(1-carbamimidoylcyclopropyl)-3-dodecylbenzamide | - |
Homo sapiens | |
N-(1-carbamimidoylcyclopropyl)-4-dodecylbenzamide | - |
Homo sapiens | |
N-[(2S)-1-amino-1-iminopropan-2-yl]-3-octylbenzamide | - |
Homo sapiens | |
VPC94075 | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + sphingosine | Homo sapiens | - |
ADP + sphingosine 1-phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9NRA0 | - |
- |
Homo sapiens | Q9NYA1 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + sphingosine | - |
Homo sapiens | ADP + sphingosine 1-phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
sphingosine kinase 1 | - |
Homo sapiens |
sphingosine kinase 2 | - |
Homo sapiens |
SPHK1 | isoform | Homo sapiens |
SPHK2 | isoform | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00004 | - |
1-[3-(3-dodecylphenyl)-1,2,4-oxadiazol-5-yl]cyclopropane-1-carboximidamide | isoform SphK1, pH and temperature not specified in the publication | Homo sapiens | |
0.000047 | - |
(2S)-1-(4-[4-[3-(2-cyclohexylethyl)phenyl]-1,3-oxazol-2-yl]benzoyl)pyrrolidine-2-carboximidamide | isoform SphK1, pH and temperature not specified in the publication | Homo sapiens | |
0.00007 | - |
1-[3-(3-undecylphenyl)-1,2,4-oxadiazol-5-yl]cyclopropane-1-carboximidamide | isoform SphK1, pH and temperature not specified in the publication | Homo sapiens | |
0.000075 | - |
(2S)-1-[3-[7-(cyclohexylmethoxy)heptyl]benzoyl]pyrrolidine-2-carboximidamide | isoform SphK1, pH and temperature not specified in the publication | Homo sapiens | |
0.0001 | - |
1-[3-(3-decylphenyl)-1,2,4-oxadiazol-5-yl]cyclopropane-1-carboximidamide | isoform SphK1, pH and temperature not specified in the publication | Homo sapiens | |
0.000125 | - |
(2S)-1-(3-dodecylbenzoyl)pyrrolidine-2-carboximidamide | isoform SphK1, pH and temperature not specified in the publication | Homo sapiens | |
0.0002 | - |
1-[5-(3-dodecylphenyl)-1,3,4-oxadiazol-2-yl]cyclopropane-1-carboximidamide | isoform SphK1, pH and temperature not specified in the publication | Homo sapiens | |
0.0002 | - |
N-(1-carbamimidoylcyclopropyl)-3-dodecylbenzamide | isoform SphK1, pH and temperature not specified in the publication | Homo sapiens | |
0.0003 | - |
1-carbamimidoyl-N-(3-dodecylphenyl)cyclopropane-1-carboxamide | isoform SphK1, pH and temperature not specified in the publication | Homo sapiens | |
0.00032 | - |
1-[3-(4-dodecylphenyl)-1,2,4-oxadiazol-5-yl]cyclopropane-1-carboximidamide | isoform SphK1, pH and temperature not specified in the publication | Homo sapiens | |
0.0004 | - |
1-[5-(3-dodecylphenyl)-1,2,4-oxadiazol-3-yl]cyclopropane-1-carboximidamide | isoform SphK1, pH and temperature not specified in the publication | Homo sapiens | |
0.00044 | - |
1-[3-(4-decylphenyl)-1,2,4-oxadiazol-5-yl]cyclopropane-1-carboximidamide | isoform SphK1, pH and temperature not specified in the publication | Homo sapiens | |
0.0005 | - |
N-(1-carbamimidoylcyclopropyl)-3-dodecylbenzamide | isoform SphK2, pH and temperature not specified in the publication | Homo sapiens | |
0.00098 | - |
1-[3-(3-tridecylphenyl)-1,2,4-oxadiazol-5-yl]cyclopropane-1-carboximidamide | isoform SphK1, pH and temperature not specified in the publication | Homo sapiens | |
0.0012 | - |
1-[5-(4-dodecylphenyl)-1,3,4-oxadiazol-2-yl]cyclopropane-1-carboximidamide | isoform SphK2, pH and temperature not specified in the publication | Homo sapiens | |
0.0015 | - |
(2S)-1-(3-dodecylbenzoyl)pyrrolidine-2-carboximidamide | isoform SphK2, pH and temperature not specified in the publication | Homo sapiens | |
0.0016 | - |
1-[5-(4-dodecylphenyl)-1,3,4-oxadiazol-2-yl]cyclopropane-1-carboximidamide | isoform SphK1, pH and temperature not specified in the publication | Homo sapiens | |
0.0025 | - |
1-[3-(4-tridecylphenyl)-1,2,4-oxadiazol-5-yl]cyclopropane-1-carboximidamide | isoform SphK1, pH and temperature not specified in the publication | Homo sapiens | |
0.003 | - |
1-[5-(4-dodecylphenyl)-1,2,4-oxadiazol-3-yl]cyclopropane-1-carboximidamide | isoform SphK1, pH and temperature not specified in the publication | Homo sapiens | |
0.003 | - |
(2S)-1-[3-[7-(cyclohexylmethoxy)heptyl]benzoyl]pyrrolidine-2-carboximidamide | isoform SphK2, pH and temperature not specified in the publication | Homo sapiens | |
0.0034 | - |
1-[5-(4-dodecylphenyl)-1,2,4-oxadiazol-3-yl]cyclopropane-1-carboximidamide | isoform SphK2, pH and temperature not specified in the publication | Homo sapiens | |
0.0042 | - |
(2S)-1-(4-[4-[3-(2-cyclohexylethyl)phenyl]-1,3-oxazol-2-yl]benzoyl)pyrrolidine-2-carboximidamide | isoform SphK2, pH and temperature not specified in the publication | Homo sapiens | |
0.0046 | - |
N-(1-carbamimidoylcyclopropyl)-4-dodecylbenzamide | isoform SphK1, pH and temperature not specified in the publication | Homo sapiens | |
0.006 | - |
1-carbamimidoyl-N-(3-dodecylphenyl)cyclopropane-1-carboxamide | isoform SphK2, pH and temperature not specified in the publication | Homo sapiens | |
0.006 | - |
1-[3-(4-decylphenyl)-1,2,4-oxadiazol-5-yl]cyclopropane-1-carboximidamide | isoform SphK2, pH and temperature not specified in the publication | Homo sapiens | |
0.008 | - |
1-[3-(4-dodecylphenyl)-1,2,4-oxadiazol-5-yl]cyclopropane-1-carboximidamide | isoform SphK2, pH and temperature not specified in the publication | Homo sapiens | |
0.0081 | - |
1-[5-(3-dodecylphenyl)-1,3,4-oxadiazol-2-yl]cyclopropane-1-carboximidamide | isoform SphK2, pH and temperature not specified in the publication | Homo sapiens | |
0.0099 | - |
1-[3-(3-undecylphenyl)-1,2,4-oxadiazol-5-yl]cyclopropane-1-carboximidamide | isoform SphK2, pH and temperature not specified in the publication | Homo sapiens | |
0.0102 | - |
1-[5-(3-dodecylphenyl)-1,2,4-oxadiazol-3-yl]cyclopropane-1-carboximidamide | isoform SphK2, pH and temperature not specified in the publication | Homo sapiens | |
0.0103 | - |
1-[3-(3-decylphenyl)-1,2,4-oxadiazol-5-yl]cyclopropane-1-carboximidamide | isoform SphK2, pH and temperature not specified in the publication | Homo sapiens | |
0.0109 | - |
N-(1-carbamimidoylcyclopropyl)-4-dodecylbenzamide | isoform SphK2, pH and temperature not specified in the publication | Homo sapiens | |
0.011 | - |
1-[3-(4-tridecylphenyl)-1,2,4-oxadiazol-5-yl]cyclopropane-1-carboximidamide | isoform SphK2, pH and temperature not specified in the publication | Homo sapiens | |
0.0117 | - |
1-[3-(3-tridecylphenyl)-1,2,4-oxadiazol-5-yl]cyclopropane-1-carboximidamide | isoform SphK2, pH and temperature not specified in the publication | Homo sapiens | |
0.0141 | - |
1-[3-(3-dodecylphenyl)-1,2,4-oxadiazol-5-yl]cyclopropane-1-carboximidamide | isoform SphK2, pH and temperature not specified in the publication | Homo sapiens | |
0.02 | - |
VPC94075 | isoform SphK2, pH and temperature not specified in the publication | Homo sapiens | |
0.043 | - |
1-[3-(4-undecylphenyl)-1,2,4-oxadiazol-5-yl]cyclopropane-1-carboximidamide | isoform SphK2, pH and temperature not specified in the publication | Homo sapiens | |
0.055 | - |
1-[3-(4-undecylphenyl)-1,2,4-oxadiazol-5-yl]cyclopropane-1-carboximidamide | isoform SphK1, pH and temperature not specified in the publication | Homo sapiens | |
0.055 | - |
N-[(2S)-1-amino-1-iminopropan-2-yl]-3-octylbenzamide | isoform SphK1, pH and temperature not specified in the publication | Homo sapiens | |
0.055 | - |
VPC94075 | isoform SphK1, pH and temperature not specified in the publication | Homo sapiens |