Application | Comment | Organism |
---|---|---|
medicine | sphingosine analogue FTY720, which is activated by phosphorylation specifically by SPHK2, mediates apoptotic signaling of cultured synovial fibroblasts | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | SPHK2 is expressed in and around the nucleus and transferred to the cytoplasm and cell surface by the administration of epidermal growth factor, associated with the increased expression of sphingosine 1-phosphate | Homo sapiens | 5737 | - |
nucleus | SPHK2 is expressed in and around the nucleus and transferred to the cytoplasm and cell surface by the administration of epidermal growth factor, associated with the increased expression of sphingosine 1-phosphate | Homo sapiens | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | SPHK2 is expressed in the synovial fibroblasts of the synovial tissues obtained from the knee joints of rheumatiod patients. In the cultured synovial fibroblasts from these patients, SPHK2 is more highly expressed than that in the human macrophage cell line, THP-1 and human dermal fibroblasts. SPHK2 is expressed in and around the nucleus and transferred to the cytoplasm and cell surface by the administration of epidermal growth factor, associated with the increased expression of sphingosine 1-phosphate. A sphingosine analogue, FTY720, which is activated by phosphorylation specifically by SPHK2, mediates apoptotic signaling of the cultured synovial fibroblasts | Homo sapiens | - |
THP-1 cell | in the cultured synovial fibroblasts from rheumatoid arthritis patients, SPHK2 is more highly expressed than in the human macrophage cell line, THP-1 and human dermal fibroblasts | Homo sapiens | - |