Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.1.91 extracted from

  • Haberberger, R.V.; Tabeling, C.; Runciman, S.; Gutbier, B.; Koenig, P.; Andratsch, M.; Schuette, H.; Suttorp, N.; Gibbins, I.; Witzenrath, M.
    Role of sphingosine kinase 1 in allergen-induced pulmonary vascular remodeling and hyperresponsiveness (2009), J. Allergy Clin. Immunol., 124, 933-41.e1-9.
    View publication on PubMed

Application

Application Comment Organism
medicine after 4 weeks of systemic ovalbumin sensitization and local airway challenge, airway responsiveness increases less in SphK1-/- compared with wild-type mice, whereas pulmonary vascular responsiveness is greatly increased and does not differ between strains. Acute lung inflammation leads to an increase in eosinophils and mRNA expression for sphingosine 1-phosphate phosphatase 2 and sphingosine 1-phosphate lyase in lungs of wild-type but not SphK1-/- mice. After repetitive allergen exposure for 8 weeks, airway responsiveness is not augmented in SphK1-/- or wild-type mice, but pulmonary vascular responsiveness is increased in both strains, with significantly higher vascular responsiveness in SphK1-/- mice compared with that seen in wild-type mice Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-