Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
BALL-1 cell | - |
Homo sapiens | - |
CMK-86 cell | - |
Homo sapiens | - |
HEL cell | - |
Homo sapiens | - |
HL-60 cell | - |
Homo sapiens | - |
JURKAT cell | - |
Homo sapiens | - |
K-562 cell | - |
Homo sapiens | - |
KOPT-K1 cell | - |
Homo sapiens | - |
KU-812 cell | - |
Homo sapiens | - |
leukemia cell | - |
Homo sapiens | - |
leukemia cell line | CMK-115 | Homo sapiens | - |
NALL-1 cell | - |
Homo sapiens | - |
NALM-17 cell | - |
Homo sapiens | - |
NB-4 cell | - |
Homo sapiens | - |
RPMI-8402 cell | - |
Homo sapiens | - |
THP-6 cell | - |
Homo sapiens | - |
U-937 cell | - |
Homo sapiens | - |
General Information | Comment | Organism |
---|---|---|
physiological function | cell lines sensitive to daunorubicin show increased ceramide content, while cell lines resistant to daunorubicin do not when treated with low doses of drug. Upon daunorubicin treatment, sphinganine 1-phosphate decreases more in the sensitive cell lines than in the resistant cell lines. A sphinganine kinase inhibitor recovers the daunorubicin sensitivity of daunorubicin resistant cells. The modulation of isoform Sk1 gene expression by overexpression or using siRNA affects the daunorubicin sensitivity of cell lines | Homo sapiens |